Bills vs Lions Prediction 9/17/26 NFL Picks Today

The Detroit Lions and Buffalo Bills meet Thursday in NFL action at Highmark Stadium. Here’s a Bills vs. Lions Prediction. This article will include a Bills vs Lions Pick.

Detroit Lions Betting Preview

The Detroit Lions beat the Saints and play the Jets next. The Detroit Lions look to start 2-0 for the first time since the 2017 season. Jared Goff is completing 66.7 percent of his passes for 206 yards, 2 touchdowns, and 0 interceptions. Amon-Ra St. Brown and Sam LaPorta have combined for 115 receiving yards and 2 touchdowns, while Jameson Williams has 4 receptions.

The Detroit Lions ground game is averaging 165 yards per contest, and Jahmyr Gibbs leads the way with 156 yards and 2 touchdowns. Defensively, Detroit is allowing 30 points and 469 yards per game. D.J. Reed leads the Detroit Lions with 10 tackles, Aidan Hutchinson has 2 sacks, and Derrick Barnes has 1 interception.

Buffalo Bills Betting Preview

The Buffalo Bills beat the Texans, and they play the Chargers next. The Bills look to start 2-0 for a third straight season. Josh Allen is completing 69 percent of his passes for 334 yards, 2 touchdowns, and 0 interceptions. Dalton Kincaid and DJ Moore have combined for 230 receiving yards and 1 touchdown, while Khalil Shakir has 4 receptions.

The Buffalo Bills ground game is averaging 86 yards per contest, and James Cook III leads the way with 57 yards on 13 carries. Defensively, Buffalo is allowing 31 points and 381 yards per game. Terrel Bernard leads the Buffalo Bills with 12 tackles, Greg Rousseau has 2 sacks, and Davison Igbinosun has 1 pass deflection.

Why the Buffalo Bills will win

• The Bills have won each of their last eight home games in September.
• The Lions have lost 14 of their last 15 Week 2 road games.
• The Lions have failed to cover the spread in each of their last six games following a win.
• The Bills have covered the spread in each of their last five Week 2 games.
• The Bills have won the first half in each of their last seven Week 2 games.
• The Lions have lost the first quarter in seven of their last eight road games following an overtime win.
• The Bills have scored the first touchdown in five of their last six Week 2 games.

Why the Detroit Lions will win

• The Lions have won each of their last six road games without Aidan Hutchinson.
• The Bills have lost five of their last seven games as favorites without Dalton Kincaid.
• The Lions have covered the spread in each of their last seven September games against AFC opponents.
• The Bills have failed to cover the spread in eight of their last nine games as favorites following a win.
• The Lions have won the first half in 10 of their last 11 road games following a home win.
• The underdogs have won the first quarter in four of the Bills’ last five games.
• The Lions have scored the first touchdown in each of their last eight games as underdogs following a home win.

Total Points Facts

• Each of the Bills’ last eight home games in September have gone OVER the total points line.
• Five of the Lions’ last six games without Aidan Hutchinson have gone OVER the total points line.

Buffalo Bills Player Prop Facts

• James Cook has recorded 74+ rushing yards in each of the Bills’ last seven games following a road win.
• Josh Allen has recorded 251+ passing yards in each of the Bills’ last four games with a total points line of at least 50.0.
• Josh Allen has scored at least one touchdown in each of the Bills’ last 10 home games against teams on a winning streak.
• Josh Allen has scored the last touchdown in three of the Bills’ last four home games against NFC opponents.
• Dawson Knox has recorded 23+ receiving yards in each of the Bills’ last eight games played on the East Coast.
• James Cook has recorded 111+ rushing and receiving yards in each of the Bills’ last four games as moderate favorites (-3.5 to -7.0 points).
• Josh Allen has scored two or more touchdowns in each of the Bills’ last four home games against teams that held a winning record.
• Heading into Week 2, Gregory Rousseau ranks T1st in the NFL in sacks (2.0) this season.

Detroit Lions Player Prop Facts

• Jahmyr Gibbs has recorded 91+ rushing yards in three of the Lions’ last four September games.
• Jared Goff has recorded 279+ passing yards in five of the Lions’ last six games with a total points line of at least 50.0.
• Jameson Williams has recorded 66+ receiving yards in each of the Lions’ last four games as underdogs.
• Jahmyr Gibbs has scored at least one touchdown in seven of the Lions’ last eight games against AFC opponents.
• Jameson Williams has recorded 66+ rushing and receiving yards in each of the Lions’ last four games as underdogs.
• Jahmyr Gibbs has scored the first touchdown in three of the Lions’ last four September games.
• Jahmyr Gibbs has scored two or more touchdowns in four of the Lions’ last five night games against teams that held a winning record.
• Jared Goff has recorded 25+ completions in each of the Lions’ last six games with a total points line of at least 50.0.
• Heading into Week 2, Aidan Hutchinson ranks T1st in the NFL in sacks (2.0) this season.

Matchup/League Facts

• Bills – two different players have recorded 70+ receiving yards in a game this season – equal-most in the NFL, heading into Week 2.
• Bills – two different players have recorded 80+ receiving yards in a game this season – tied for most in the NFL, heading into Week 2.
• Lions – two different players have recorded multi-touchdown games this season – equal-most in the NFL, heading into Week 2.
• Lions – four different players have recorded 1.0 sacks or more in a game this season – equal-most in the NFL, heading into Week 2.

Bills vs Lions Prediction

We’re seeing defenses struggle across the league early in the season, and it has me looking at overs. That’s the case here as well with a quick turnaround. The Lions and Bills each topped 30 points last week, and that includes Buffalo averaging 7.9 yards per play against an elite Texans defense on the road. The Lions defense allowed 29 first downs at home to the Saints and was absolutely carved up by Tyler Shough. This feels like a back-and-forth, high-scoring game between two high-powered offenses. Give me the over.