Cubs vs Marlins Prediction 9/22/26 MLB Picks Today
Miami Marlins (76-80) vs. Chicago Cubs (87-69)
September 22, 2026 7:40 pm EDT
The Line: Chicago Cubs -218 / Miami Marlins 178; Over/Under: 6.5
(Get latest betting odds)
In this article we will formulate a Cubs vs Marlins prediction for this MLB game on Tuesday, September 22nd at Wrigley Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup.
Chicago Cubs Betting Preview
The Chicago Cubs are 87-69 this year after they won two out of three against the Reds by scores of 4-6, 5-2, and 9-1. In game three, Chicago scored eight runs in the first five innings and picked up the easy win. The Cubs recorded 13 hits and they committed one error in the game, while they were led by Crow-Armstrong, who went 3-5 with one home run and two RBIs. Peterson allowed three hits and one earned run over 6.0 innings for the win, while Rea threw an inning in relief. Prior to that series, Chicago won two out of three against the Braves and two out of three against the Pirates.
This season, Chicago has a 4.16 ERA with a 1.26 WHIP and a .243 opponent batting average, while they have scored 835 runs with a .252 batting average and a .340 on base percentage. Pete Crow-Armstrong has led the Cubs with 45 home runs and 107 RBIs, while Dansby Swanson has added 19 home runs and 67 RBIs. The projected starting pitcher for Chicago is Kevin Gausman, who is 9-12 with a 4.55 ERA and a 1.27 WHIP over 172.0 innings pitched this year.
Miami Marlins Betting Preview
The Miami Marlins are 76-80 this season after they lost all three against the Padres by scores of 2-8, 6-7, and 3-7. In game three, Miami cut the deficit to 4-3 in the seventh inning, but allowed the last three runs to seal the loss. The Marlins recorded four hits and they committed one error in the game, while they were led by Sanoja, who went 1-3 with one home run and three RBIs. Alcantara allowed eight hits and four earned runs over 6.0 innings for the loss, while Blalock allowed three earned runs in relief. Prior to that series, Miami won two out of three against the Diamondbacks and two out of three against the Dodgers.
This season, Miami has a 4.16 ERA with a 1.29 WHIP and a .237 opponent batting average, while they have scored 692 runs with a .249 batting average and a .327 on base percentage. Otto Lopez has led the Marlins with 11 home runs and 71 RBIs, while Owen Caissie has added 14 home runs and 58 RBIs. The projected starting pitcher for Miami is Janson Junk, who is 6-9 with a 4.50 ERA and a 1.34 WHIP over 114.0 innings pitched this season.
Why the Chicago Cubs will win
- The Cubs have won each of their last nine night games against NL East opponents that held a losing record.
- The Marlins have lost 14 of their last 16 road games against teams that held a winning record.
- The Cubs have covered the run line in eight of their last nine night games against NL East opponents that held a losing record.
- The Cubs have won the first inning in three of their last four home games against opponents that held a losing record.
- The Cubs have led after 3 innings in seven of their last eight home games.
- The Cubs have led after 5 innings in each of their last seven home games.
Why the Miami Marlins will win
- The Cubs have lost five of their last six games as home favorites following a win.
- The underdogs have won 15 of the Marlins’ last 23 games.
- The Cubs have failed to cover the run line in each of their last 12 games as home favorites following a win.
- The Marlins have covered the run line in eight of their last nine night games against NL Central opponents.
- The Marlins have led after 3 innings in each of their last three night games.
Total Runs Facts
- Each of the Cubs’ last six home games against NL East opponents have gone OVER the total runs line.
- Nine of the Marlins’ last 11 road games against NL Central opponents have gone UNDER the total runs line.
- There has been no run scored during the first inning in each of the Marlins’ last 13 games against NL Central opponents.
- There has been no run scored during the first inning in 15 of the Cubs’ last 17 games against NL East opponents.
Chicago Cubs Player Prop Facts
- Kevin Gausman has recorded six or more strikeouts in each of his last six appearances against NL opponents.
- Kevin Gausman has recorded a win in three of his last four home appearances against NL opponents.
- Nico Hoerner has recorded at least one hit in each of his last 12 appearances after not playing the previous day.
- Seiya Suzuki has hit a home run in each of the Cubs’ last three home games against NL East opponents that held a losing record.
Miami Marlins Player Prop Facts
- Kyle Stowers has hit at least one home run in each of the Marlins’ last two road games against the Cubs.
- Janson Junk has recorded three or more strikeouts in each of his five previous appearances in night games against NL Central teams that held a winning record.
- Xavier Edwards has recorded at least one hit in each of his last eight appearances in night games against NL Central teams that held a winning record.
Matchup/League Facts
- The Cubs rank 1st in the league for runs scored this season (835).
- The Cubs rank 1st in the league for home runs this season (217).
- The Marlins rank T2nd in the league for steals this season (159).
- The Marlins rank 3rd in the league for triples this season (35).
Cubs vs Marlins Prediction
Miami comes into this matchup after getting swept by the Padres and they allowed 22 runs in those three games. The Marlins are 31-47 on the road this year, while the Cubs are 45-33 at home. Chicago has won three of their last four games and they have scored 22 runs in those three wins. The Cubs are starting Gausman, who has allowed 2, 6, 1, 5, and 0 earned runs in his last five starts, while Junk has allowed 1, 8, 1, 1, and 0 earned runs in his last five outings. Take the Cubs -1.5 here.