College Football

SMU vs Missouri State Prediction Football Picks Today 9/26/26

Missouri State Bears (1-2) vs. SMU Mustangs (2-1)
September 26, 2026 9:00 pm EDT
The Line: SMU Mustangs -34.5 / Missouri State Bears +34.5; Over/Under: 59.5
(Get latest betting odds)

The Missouri State Bears and the SMU Mustangs meet in week 4 college football action from Gerald J. Ford Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Missouri State Bears vs. SMU Mustangs Prediction.

Missouri State Bears Recap

The Missouri State Bears come into this game looking to rebound from a 30-24 loss at the hands of Marshall last time out to sit at 1-2 this season. After this game, Missouri State will head home for a game against Delaware.

Bears Looking To Rebound With Upset Win

Skyler Locklear has thrown for 597 yards, 3 touchdowns and 1 interception on 67.7% passing while Ramone Green Jr. leads Missouri State in rushing with 159 rushing yards and 2 touchdowns so far this season. Breezy Dubar sits behind Green Jr. on the ground with 118 yards and 2 TDs. Isaiah Myers leads the Bears in receiving with 296 yards on 12 catches along with 1 touchdown, while Jmariyae Robinson trails with 93 yards on 12 catches. On defense, Jared Lloyd has a team-high 32 total tackles and leads the team with 1 sack, while Jashawn Cooper recorded 1 interception. Missouri State’s defense as a whole has combined for 5 sacks and 1 interception so far this season.

SMU Mustangs Recap

The SMU Mustangs come into this game looking to bounce back from their 41-31 loss at the hands of Louisville last time out to sit at 2-1 this season. After this game, SMU will take on Boston College in a matchup at home.

Mustangs Looking To Rebound From Double-Digit Defeat

Kevin Jennings has thrown for 989 yards, 9 touchdowns and 4 interceptions on 73.6% passing while Kendrick Raphael leads SMU in rushing with 275 rushing yards and 4 touchdowns so far this season. Dramekco Green sits behind Raphael on the ground with 85 yards and 0 TDs. Yamarion Smith leads the Mustangs in receiving with 201 yards on 9 catches, while Yamir Knight trails with 181 yards on 16 catches along with 1 touchdown. On defense, Tyson Polley Jr. has a team-high 18 total tackles, while Jimmy Wyrick leads the team with 2 sacks, and Jarvis Lee recorded 1 interception. SMU’s defense as a whole has combined for 5 sacks and 1 interception so far this season.

Missouri State Bears @ SMU Mustangs Betting Trends: Week 4

 

Why the SMU Mustangs will win

  • SMU has won each of its last six games against opponents from the Conference USA.
  • Missouri State has lost five of its last six games.
  • SMU has covered the spread in each of its last nine games against opponents from the Conference USA at Gerald J. Ford Stadium.
  • Missouri State has failed to cover the spread in each of its last four games as an underdog.
  • SMU has won the first quarter in each of its last eight home games against non-AP-ranked teams.
  • SMU has won the first half in each of its last 19 games as a favorite in Texas.

Why the Missouri State Bears will win

  • SMU has failed to cover the spread in seven of its last eight games as an AP-ranked team.

Total Points Facts

  • Each of SMU’s last four home games in September have gone OVER the total points line.
  • Six of Missouri State’s last seven games have gone OVER the total points line.

SMU Mustangs Player Prop Facts

  • Heading into Week 4, Kevin Jennings ranks 6th amongst FBS players for passing yards (989) this season.

Missouri State Bears Player Prop Facts

  • Heading into Week 4, Isaiah Myers ranks 12th amongst qualified players for Yards Per Reception (24.7) this season.

Matchup/League Facts

  • SMU ranks 2nd among FBS teams for passing yards per game this season (368.7).
  • SMU ranks T4th among FBS teams for Q2 opponent points per game this season (1.0).
  • Missouri State has lost the fourth quarter in each of its last three games – equal-longest active streak in the FBS.
  • Missouri State ranks T136th among FBS teams for Q4 points per game this season (0.0).

Missouri State Bears vs. SMU Mustangs Prediction

I’m on the Mustangs in this one. It’s a big number here, but the problem I have is that Missouri State didn’t show up in their lone major step up spot against Texas A&M and this feels like a name your number spot for SMU. The Bears gave up big numbers to Texas A&M This year and USC last season and I think this is a rout. Give me SMU.

Chris Ruffolo's Free Pick: SMU Mustangs -34.5

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Chris Ruffolo

Chris joined the Sports Chat Place team in August 2016 and has a proven system that combines multiple analytical and situational statistics and trends to give out thousands of winning picks over the last three years with winning records across all of the top leagues, Follow Chris Ruffolo on Twitter @ruffthepickdawg

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