Red Sox vs Cubs Prediction 9/25/26 MLB Picks Today

The Chicago Cubs and Boston Red Sox meet Friday in an MLB doubleheader at Fenway Park. Here’s a Red Sox vs. Cubs Prediction. This article will include a Red Sox vs. Cubs Pick.

Chicago Cubs Betting Preview

The Chicago Cubs are 88-71 on the year. The Chicago Cubs are batting .251 on the season, with a .339 OBP and a .429 slugging percentage. The Chicago Cubs’ pitching staff has a 4.15 ERA and a 1.26 WHIP. Pete Crow-Armstrong leads the Chicago Cubs with 173 hits and 107 RBI, while Alex Bregman and Nico Hoerner have combined for 320 hits and 161 RBI.

Clay Holmes and David Peterson get the ball for the Chicago Cubs.

Boston Red Sox Betting Preview

The Boston Red Sox are 85-74 on the year. The Boston Red Sox are batting .246 on the season, have a .319 OBP, and have a .399 slugging percentage. The Boston Red Sox pitching staff has a 3.55 ERA and a 1.23 WHIP. Ceddanne Rafaela leads the Boston Red Sox with 152 hits and 70 RBI, while Wilyer Abreu and Caleb Durbin have combined for 272 hits and 138 RBI.

Alec Gamboa and Brayan Bello get the ball for the Boston Red Sox.

Why the Boston Red Sox will win

• The Red Sox have won each of their last five games as underdogs against NL opponents.
• The Cubs have lost four of their last five games as favorites following a win.
• The Red Sox have covered the run line each of their last 11 Friday games against teams that held a winning record.
• The Cubs have failed to cover the run line in nine of their last 10 games following a home win.
• The Cubs have lost the first inning in three of their last four games at Fenway Park.
• The Cubs have trailed after 3 innings in five of their last six games at Fenway Park.
• The Cubs have trailed after 5 innings in each of their last four day games against AL East opponents.

Why the Chicago Cubs will win

• The Cubs have won 14 of their last 16 road games against AL opponents following a home win.
• The Red Sox have lost four of their last five games.
• The Cubs have covered the run line in eight of their last nine road games against AL opponents.
• The Red Sox have failed to cover the run line in 11 of their last 12 games following a loss.
• The Cubs have led after 3 innings in each of their last four games against opponents that held a winning record.
• The Cubs have led after 5 innings in each of their last four games against opponents that held a winning record.

Total Runs Facts

• Each of the Red Sox’s last seven games have gone UNDER the total runs line.
• Each of the Cubs’ last four road games against AL opponents have gone OVER the total runs line.
• There has been at least one run scored in the first inning in each of the Cubs’ last six road games against AL opponents.
• There has been no run scored during the first inning in nine of the Red Sox’s last 10 home games.

Boston Red Sox Player Prop Facts

• Ceddanne Rafaela has hit at least one home run in each of the Red Sox’s last three games as underdogs against NL opponents.
• Trevor Story has recorded at least one hit in each of his last 16 home appearances against NL Central opponents that held a winning record.

Chicago Cubs Player Prop Facts

• Ian Happ has hit a home run in four of the Cubs’ last five road games against AL opponents.
• Clay Holmes has recorded five or more strikeouts in four of his last five appearances with his team as a road favorite against AL opponents.
• Alex Bregman has recorded at least one hit in each of his last 14 appearances against the Red Sox.
• Pete Crow-Armstrong ranks T1st in the league in Home Runs (45) this season.

Matchup/League Facts

• The Red Sox rank T1st in the league for home runs allowed this season (151).
• The Red Sox rank 2nd in the league for doubles this season (281).
• The Cubs rank 1st in the league for runs scored this season (841).
• The Cubs rank 1st in the league for RBIs this season (795).

Red Sox vs Cubs Prediction

Game 1 Prediction: I’m not a fan of openers, but the Red Sox have the edge with the quick start at home. Also, Holmes has been a mess lately, allowing 14 hits and 16 earned runs in his last 15.1 innings. Holmes also has a 4.44 ERA through 50.2 innings on the road compared to a 1.94 ERA in 46.1 innings at home. I’ll roll with the Red Sox at home in game 1.

Game 2 Prediction: Peterson has been hittable all season, and that includes allowing 19 hits and 9 runs in his last 20 innings. Peterson has a control issue and has walked 14 batters in his last 25 innings. Bello has found his form lately, allowing 9 hits and 1 run in his last 14.2 innings. It’s hard to sweep a doubleheader, but I like the Red Sox in both games on Friday.