Giants vs Dodgers Prediction 9/25/26 MLB Picks Today
LA Dodgers (97-62) vs. San Francisco Giants (65-94)
September 25, 2026 10:15 pm EDT
The Line: San Francisco Giants 300 / LA Dodgers -388; Over/Under: 7.5
(Get latest betting odds)
The Los Angeles Dodgers and San Francisco Giants meet Friday in MLB action at Oracle Park. Here’s a Giants vs. Dodgers Prediction. This article will include a Giants vs. Dodgers Pick.
Los Angeles Dodgers Betting Preview
The Los Angeles Dodgers are 97-62 this year. The Los Angeles Dodgers are batting .257 on the season, with a .339 OBP and a .425 slugging percentage. The Los Angeles Dodgers’ pitching staff has a 3.59 ERA and a 1.15 WHIP. Freddie Freeman leads the Los Angeles Dodgers with 167 hits and 70 RBI, while Andy Pages and Shohei Ohtani have combined for 279 hits and 161 RBI.
Tarik Skubal gets the ball for the Los Angeles Dodgers, and he is 11-7 with a 2.85 ERA and 176 strikeouts this season. Skubal is 2-1 with a 4.30 ERA and 17 strikeouts in his career against the San Francisco Giants.
San Francisco Giants Betting Preview
The San Francisco Giants are 65-94 this year. The San Francisco Giants are batting .246 on the season, have a .308 OBP, and have a .403 slugging percentage. The San Francisco Giants’ pitching staff has a 4.36 ERA and a 1.36 WHIP. Jung Hoo Lee leads the San Francisco Giants with 149 hits and 57 RBI, while Rafael Devers and Willy Adames have combined for 251 hits and 149 RBI.
Yunior Marte gets the ball for the San Francisco Giants, and he is 0-1 with a 4.66 ERA and 11 strikeouts this season. This will be Marte’s second career game against the Los Angeles Dodgers.
Why the San Francisco Giants will win
- The home team has won each of the last five games between the Dodgers and Giants.
- The Dodgers have lost three of their last four games as favorites against NL West opponents following a home loss.
- The home team has covered the run line in each of the last five games between the Dodgers and Giants.
- The Dodgers have failed to cover the run line in seven of their last eight games against NL West opponents following a loss.
- The Giants have led after 5 innings in five of their last six home night games.
- The Giants have won the first inning in six of their last seven home games against NL opponents.
- The Giants have led after 3 innings in four of their last five games against NL opponents.
Why the Los Angeles Dodgers will win
- The Giants have lost each of their last 12 Friday night games against NL opponents.
- The Dodgers have won each of their last six games against NL West opponents that held a losing record.
- The Giants have failed to cover the run line in each of their last nine Friday games against NL opponents.
- The Dodgers have covered the run line in 10 of their last 11 night games at Oracle Park following a loss.
- The Dodgers have led after 3 innings in four of their last five night games against the Giants.
- The Dodgers have led after 5 innings in each of their last four road games against NL West opponents that held a losing record.
- The Dodgers have won the first inning in four of their last five night games against the Giants.
Total Runs Facts
- Each of the Giants’ last five night games against NL West opponents have gone OVER the total runs line.
- Each of the Dodgers’ last four games have gone UNDER the total runs line.
- There has been at least one run scored in the first inning in 15 of the Giants’ last 16 night games against NL opponents.
- There has been no run scored during the first inning in nine of the Dodgers’ last 11 road games against NL West opponents.
San Francisco Giants Player Prop Facts
- Victor Bericoto has hit a home run in two of his last three appearances in night games against NL West teams that held a winning record.
- Andrew Knizner has recorded a hit in each of his last five home appearances.
Los Angeles Dodgers Player Prop Facts
- Tarik Skubal has recorded a win in each of his last four appearances against NL opponents that held a losing record.
- Tarik Skubal has recorded nine or more strikeouts in three of his last four road appearances against opponents that held a losing record.
- Will Smith has hit a home run in three of the Dodgers’ last four games against the Giants.
- Andy Pages has recorded at least one hit in each of his last seven road appearances.
Matchup/League Facts
- The Giants rank 30th in the league for walks this season (446).
- The Giants rank 29th in the league for on-base percentage this season (.308).
- The Dodgers rank 1st in the league for opponent batting average this season (.219).
- The Dodgers rank 1st in the league for hits allowed this season (1142).
Giants vs Dodgers Prediction
The Dodgers have burned me over the last couple of days, but there’s only one way to go here. Not only are the Dodgers in a different zip code in terms of form, but Skubal has got comfortable with his new team and is rocking a 0.99 ERA on the season. Marte has just 19.1 big league innings under his belt, and he’s facing this Dodgers lineup. I have to side with the Dodgers, and of course I’ll lay the RL to shave down the price.