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LA Chargers vs Denver Broncos Prediction 10/11/26 NFL Picks Today

Denver Broncos (2-2) vs. LA Chargers (0-4)
October 11, 2026 4:05 pm EDT
The Line: LA Chargers +3.5; Over/Under: 41.5
(Get latest betting odds)

The Denver Broncos and the Los Angeles Chargers meet in week 5 NFL action from SoFi Stadium on Sunday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Denver Broncos vs. Los Angeles Chargers prediction.

Denver Broncos Recap

The Denver Broncos come into this game looking to bounce back from their 24-14 loss at the hands of San Francisco last time out to sit at 2-2 this season. After this game, the Broncos will head home for a game against Seattle.

Broncos Have Two-Game Win Streak Snapped

Bo Nix has thrown for 819 yards, 5 touchdowns and 3 interceptions on 60.0% passing while J.K. Dobbins leads Denver in rushing with 161 yards through 4 games this season. RJ Harvey sits behind Dobbins on the ground with 49 yards. Jaylen Waddle leads the Broncos in receiving with 185 yards and 16 catches along with a touchdown, while Pat Bryant trails with 133 yards and 9 catches along with a touchdown. On defense, Alex Singleton has a team-high 47 tackles while Denver’s defense as a whole has combined for 8 sacks and 4 interceptions through 4 games this season.

Los Angeles Chargers Recap

The Los Angeles Chargers come into this game looking to shake off their 30-23 loss at the hands of Seattle last time out to sit at 0-4 this season. After this game, the Chargers will head on the road for a game against the Kansas City Chiefs.

Chargers Drop 4th Straight To Start Year

Justin Herbert has thrown for 816 yards, 4 touchdowns and 6 interceptions on 59.7% passing while Omarion Hampton leads Los Angeles in rushing with 238 yards and 3 touchdowns through 4 games this season. Keaton Mitchell sits behind Hampton on the ground with 124 yards. Tre’ Harris leads the Chargers in receiving with 209 yards and 13 catches, while Ladd McConkey trails with 183 yards and 12 catches along with a touchdown. On defense, Daiyan Henley has a team-high 26 tackles while Los Angeles’s defense as a whole has combined for 10 sacks and 4 interceptions through 4 games this season.

Denver Broncos @ Los Angeles Chargers Betting Trends: Week 5

 

Why the Los Angeles Chargers will win

  • The Broncos have lost each of their last seven games as favorites in California.
  • The underdogs have won seven of the Broncos’ last eight Week 5 games.
  • The home team has covered the spread in each of the Broncos’ last eight games.
  • The Broncos have failed to cover the spread in each of their last seven games as favorites in California.
  • The Broncos have lost the first quarter in each of their last seven games as favorites in California.
  • The Broncos have lost the first half in each of their last seven games as favorites in California.
  • The Chargers have scored the first touchdown in each of their last four games as underdogs in California.

Why the Denver Broncos will win

  • The Broncos have won each of their last 11 games as favorites against opponents on a losing streak.
  • The Chargers have lost each of their last seven games.
  • The Broncos have covered the spread in each of their last eight games as favorites without Alex Singleton.
  • The Chargers have failed to cover the spread in each of their last seven games.
  • The Chargers have lost the first quarter in five of their last six Week 5 games against AFC West opponents.
  • The Broncos have won the first half in seven of their last eight October games as favorites.
  • The Broncos have scored the first touchdown in seven of their last eight games as favorites following a road loss.

Total Points Facts

  • Each of the Broncos’ last seven games following a loss have gone UNDER the total points line.
  • Each of the Chargers’ last seven October home games against AFC West opponents have gone UNDER the total points line.
  • Seven of the last eight games between teams from the same division have gone OVER the total points line.

Los Angeles Chargers Player Prop Facts

  • Omarion Hampton has scored a touchdown in each of the Chargers’ last five games played on the West Coast.
  • Justin Herbert has recorded 19+ completions in each of his last six appearances with the Chargers as underdogs against AFC opponents.
  • Omarion Hampton has recorded 43+ rushing yards in each of his nine previous Sunday regular season appearances.
  • Justin Herbert has recorded 210+ passing yards in 13 of his 14 previous appearances with the Chargers as underdogs against AFC West opponents.
  • Kimani Vidal has recorded 10+ receiving yards in each of the Chargers’ last four October games.
  • Omarion Hampton has recorded 53+ rushing and receiving yards in each of his six previous regular season appearances with the Chargers as underdogs.
  • Heading into Week 5, Genesis Smith has recorded the equal-most interceptions in a single game this season (2 vs Bills, Week 3).

Denver Broncos Player Prop Facts

  • Courtland Sutton has scored the last touchdown in three of the Broncos’ last four October games against AFC West opponents.
  • RJ Harvey has scored at least one touchdown in each of the Broncos’ last four road games against teams that held a losing record.
  • Bo Nix has recorded 22+ completions in each of the Broncos’ last six games as favorites following a loss.
  • J.K. Dobbins has recorded 53+ rushing yards in eight of his nine previous road appearances against division opponents.
  • Evan Engram has recorded 30+ receiving yards in each of his last 12 October appearances with his team as a favorite.
  • Jarrett Stidham has recorded 219+ passing yards in four of his five previous appearances as a starter.
  • J.K. Dobbins has recorded 55+ rushing and receiving yards in each of his seven previous appearances at SoFi Stadium.
  • Heading into Week 5, Talanoa Hufanga has recorded the equal-most interceptions in a single game this season (2 vs Rams, Week 3).

Matchup/League Facts

  • Heading into Week 5, the Chargers have lost the second quarter in each of their last four games – equal-longest active streak in the league.
  • Heading into Week 5, the Chargers have averaged just 12.2 points over their last six games – fewest in the league over that span.
  • Heading into Week 5, the Broncos rank 32nd in the NFL in H1 points per game (3.3) this season.
  • Heading into Week 5, the Broncos have recorded the equal-most game with at least one Passing, one Rushing and one D/ST Touchdown (1) this season.

Denver Broncos vs. Los Angeles Chargers Prediction

I’m on the Broncos in this one. Bo Nix has been fantastic in his career as a favorite, and the Chargers for me just look broken and are now in the midst of a stretch that could have them guaranteed to finish below .500 by the end of it. Denver is still quality despite their loss to San Fran and I think the Broncos get the win and cover here.

Chris Ruffolo's Free Pick: Denver -3.5

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Chris Ruffolo

Chris joined the Sports Chat Place team in August 2016 and has a proven system that combines multiple analytical and situational statistics and trends to give out thousands of winning picks over the last three years with winning records across all of the top leagues, Follow Chris Ruffolo on Twitter @ruffthepickdawg

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