Clemson vs Duke Prediction 2/8/25 College Basketball Picks Today

The Duke Blue Devils and the Clemson Tigers meet Saturday in college basketball action from Littlejohn Coliseum. Here’s a Clemson vs Duke prediction. We will look at this from a betting perspective and determine the best Clemson vs Duke pick.

Duke Blue Devils Betting Preview

Duke has been one of the most consistent teams in the nation so far. They’re sitting on a long streak of wins, last tasting defeat way back in late November. The Devils opened on a 4-2 run with losses to Kentucky and Kansas among wins over Maine, Army, Wofford and Arizona. Since then Duke has hit a victory stretch over Seattle U, Auburn, Louisville, Incarnate Word, George Mason, Georgia Tech, Virginia Tech, SMU, Pitt, Notre Dame, Miami, Boston College, Wake Forest, NC State, North Carolina and Syracuse in succession. That gives the Blue Devils a very nice 20-2 overall run through their first 22 games of the 2025-25 season so far.

In the Syracuse matchup back on Wednesday, the Blue Devils kicked off the first half with a commanding run 37-23. Duke kept it strong in the second half with a 46-31 advantage, eventually taking the victory 83-54 in blowout fashion on the road. Leading the team in scoring was Tyrese Proctor with 16 points, two rebounds, two assists and a steal. Kon Knueppel added 12 points with two rebounds and two steals, while Cooper Flagg put up 11 points with five rebounds and two assists. Tops off the bench was Isaiah Evans with 10 points and four assists.

Clemson Tigers Betting Preview

Over on the Tigers’ side, they’ve been quite the consistent team themselves. Clemson has only lost consecutive games once so far this year. The Tigers beat Charleston Southern, St. Francis PA, Eastern Kentucky, Radford, San Francisco, Penn State, Florida A&M, Kentucky and Miami (with a loss to Boise State) during a 9-1 opening stretch. Following a 3-3 run that featured losses to Memphis, South Carolina and Louisville, the Tigers hit another win streak over Florida State, Georgia Tech, Pitt, Syracuse, Virginia Tech and NC State. Clemson’s latest outing was a tough loss to Georgia Tech however, giving the Tigers an 18-5 record through 23 games.

In the rematch versus Georgia Tech at home on Tuesday, the Tigers kicked off the first half on a 34-33 advantage. Clemson eventually slipped and had to go to overtime, filing 89-86 after two extra periods. Tops in scoring was Chase Hunter with 28 points, seven boards, four assists and five steals. Ian Schieffelin wasn’t far behind on 23 points with eight rebounds, three blocks and one assist, while Chauncey Wiggins added 15 points with six boards and two steals.

Why the Clemson Tigers will win

• Clemson has won 11 of its last 12 night games at Littlejohn Coliseum.
• Duke has lost three of its last four games at Littlejohn Coliseum against non-AP-ranked opponents.
• Clemson has won the first half in each of its last 10 night games at Littlejohn Coliseum.

Why the Duke Blue Devils will win

• Duke has won each of its last 18 games against non-AP-ranked opponents.
• Clemson has lost 32 of its last 42 night games against AP-ranked opponents.
• Duke has won the first half in 13 of its last 14 road games against non-AP-ranked opponents.

Total Points Facts

• Each of Duke’s last eight road night games against the Atlantic Coast Conference have produced a total of 137+ points.
• Each of Clemson’s last eight night games against Top 10 AP-ranked opponents have produced a total of 136+ points.

Clemson vs Duke Prediction

I’m going to stay with Duke here, but you could argue it either way. Some of the luster has worn off this matchup following the Tigers’ loss to Georgia Tech, but it should still be a fun matchup. In any case, the Blue Devils had no trouble at all with Syracuse during their latest blowout road win, shooting a nice 56.6 percent from the field with 23 points off 14 Orange turnovers. Duke is cruising right now, as they’ve hit 70 or more points in 14 of the 16 wins during this current streak.

As for Clemson, they shot a rough 36.4 percent from the field with a 56-46 rebounding deficit in their 2OT loss to Georgia Tech. The Tigers also gave up 13 turnovers for 16 Yellow Jackets points—they won’t be able to do that against Duke.

Even so, you could still make a valid case for Clemson powering one out at home here. The Tigers have been close in most of their five losses this year, as three of them have gone to overtime. Still, with the Blue Devils demolishing all comers these days, I’m leaning more toward Duke on Saturday. Should still be a fun one to watch, though.