Clemson vs Syracuse Pick – Basketball Predictions & Odds 2/22/23

Clemson vs Syracuse Pick – Basketball Predictions & Odds 2/22/23 player photo
Credit: USA Today Sports

The Syracuse Orange and the Clemson Tigers meet in college basketball action from the Littlejohn Coliseum on Wednesday night. Let’s dive into the odds, injuries, matchup history and make a prediction for this game.


Clemson comes into this game as a 3.5-point home favorite with the total for this game set at 143.5 points.


For Syracuse, Peter Carey is out for the season with a knee injury while Clemson’s injury list is clean coming into this game.

Matchup History

Syracuse’s 91-78 win over Clemson made it back-to-back wins for the Orange and seven straight wins for the home team in this head-to-head matchup.


Syracuse is 5-1 ATS in their last 6 road games and 6-2-1 ATS in their last 9 games overall while the over is 6-1 in their last 7 road games. Clemson is 9-4 ATS in their last 13 games against a team with a winning record and 4-1 ATS in their last 5 home games while the over is 4-0 in their last 4 games overall.


I’m backing Clemson here. This just feels like a great buy-low spot on Clemson, who really fell off in recent games after starting conference play so, so well. Syracuse is a solid group, but I didn’t like how they looked against Duke and now going on the road to face a somewhat desperate Clemson team eager to get back on track, is going to be a somewhat tall task. Give me the Tigers laying the points.

Chris Ruffolo's Free Pick:Clemson -3.5