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Creighton vs DePaul Prediction 2/26/25 College Basketball Picks Today

DePaul (11-17) vs. Creighton (19-8)
February 26, 2025 9:00 pm EDT
The Line: Creighton -16.5; Over/Under: 145.5
(Get latest betting odds)

The Depaul Blue Demons and the Creighton Bluejays meet Wednesday in college basketball action from the CHI Health Center Omaha. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Depaul vs. Creighton prediction.

Matchup History

The Creighton Bluejays won the first meeting between these two teams this season by a final score of score of 73-49 at Depaul back on January 21st, 2025. Depaul has not logged a win in this matchup since 2005.


Depaul Recap

The Depaul Blue Demons come into this game looking to bounce back from an 84-72 loss at the hands of Butler last time out to slip to 11-17 on the year. After this game, Depaul will head on the road for a matchup with Providence.

Blue Demons Lose 5th In A Row

CJ Gunn leads the Blue Demons in scoring with 12.2 PPG along with 3.9 RPG while Jacob Meyer has 10.5 PPG with 3.2 RPG as the only other double-digit scorer for Depaul so far this season. Isaiah Rivera has 9.9 PPG with 3.5 RPG while NJ Benson has 8.5 PPG with a team-high 6.1 RPG to lead Depaul on the glass so far this season. Conor Enright also has a team-high 6.2 APG to lead the Blue Demons in the assist department up to this point in the year. As a team, Depaul is averaging 72.2 PPG on 43.7% shooting from the field, 33.7% from three, and 70.7% from the foul line this season.

Why the DePaul Blue Demons will win

  • Creighton has lost four of its last five night games following a home win.
  • The road team has won three of the last four games between DePaul and Creighton.

Creighton Recap

The Creighton Bluejays come into this game looking to build on their 80-69 win over Georgetown last time out to improve to 19-8 on the year. After this game, Creighton will head on the road for a matchup with Xavier.

Bluejays Looking To Build Momentum Down The Stretch

Ryan Kalkbrenner leads the Bluejays in scoring and rebounding with 18.7 PPG and 8.5 RPG while Steven Ashworth has 17.1 PPG with 4.2 RPG and a team-leading 7 APG to lead the Bluejays in the assist department up to this point in the year. Jamiya Neal has 12 PPG with 6.1 RPG and 4.2 APG to cap off the scoring in double figures for the Bluejays so far this season. Jackson McAndrew has 7.3 PPG with 4.3 RPG as well on the year for Creighton. As a team, Creighton is averaging 75.3 PPG on 47% shooting from the field, 33.8% from three, and 74.9% from the foul line so far this season.

Why the Creighton Bluejays will win

  • Creighton has won each of its last 21 games against DePaul.
  • DePaul has lost 27 of its last 28 night games against the Big East Conference.

Total Points Facts

  • Eight of Creighton’s last nine night games against Conference opponents at CHI Health Center Omaha have produced a total of 147+ points.
  • Six of DePaul’s last seven night games against Conference opponents have produced a total of 141 or fewer points.

Depaul vs. Creighton Prediction

I’m on Creighton here. I think the Bluejays are just the better team in this matchup and historically, Depaul has had no luck against the Bluejays in past seasons. This is the norm for Depaul this time of year. Show up, get crushed in conference play. Creighton has cooled off a bit from their strong run of form, but I still think that the Bluejays are the better team by a fair margin and get it done at home here. Give me Creighton in this one.

Chris Ruffolo's Free Pick: Creighton -16.5

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Chris Ruffolo

Chris joined the Sports Chat Place team in August 2016 and has a proven system that combines multiple analytical and situational statistics and trends to give out thousands of winning picks over the last three years with winning records across all of the top leagues, Follow Chris Ruffolo on Twitter @ruffthepickdawg

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