Duke vs Houston Prediction 4/5/25 College Basketball Picks Today

In this article we will formulate a Duke vs Houston prediction for this College Basketball game on Saturday, April 5th at the Alamodome in San Antonio, Texas. Let’s take a look at the prediction for this game in the Final Four of the NCAA Tournament. 

Duke Blue Devils Betting Preview

The Duke Blue Devils are 35-3 (19-1) this year after they defeated Alabama by a score of 85-65 in their last game. Duke led 46-37 at halftime and held a very high scoring Alabama team to just 28 points in the second half for the easy win. The Blue Devils shot 53.6% from the field, 46.2% on three pointers, and 86.4% on free throws in the game. Kon Knueppel led Duke with 21 points and five assists, while Tyrese Proctor added 17 points and five rebounds in the win. Duke was very efficient on offense once again in this game, but their defense was great and they held Alabama to just 35.4% shooting from the field. 

Prior to that victory, the Blue Devils defeated Arizona by a score of 100-93 and Baylor by a score of 89-66. Duke has won 15 games in a row and they finished first in the ACC standings with a 19-1 record. Duke has scored 83.7 points per game and they have allowed 62.6 points against per game, while also averaging 38.3 rebounds and 17.1 assists per game this season. Cooper Flagg is averaging 18.9 points, 7.5 rebounds, and 4.2 assists per game, while Kon Knueppel is averaging 14.4 points, 3.9 rebounds, and 2.8 assists per game this year. Duke is shooting 48.8% from the field, 78.4% on free throws, and 37.7% on three pointers this season. 

Houston Cougars Betting Preview

The Houston Cougars are 34-4 (19-1) this season after they defeated Tennessee by a score of 69-50 in their last game. Houston led 34-15 at halftime and they were able to win comfortably, despite allowing 35 points in the second half. The Cougars shot 42.4% from the field, 36% on three pointers, and 100% on free throws in the game. LJ Cryer led Houston with 17 points and seven rebounds, while Emanuel Sharp added 16 points and two rebounds in the game. Houston played terrific defense once again in this game and they held Tennessee to just 28.8% from the field and 17.2% on three pointers in the win. 

Prior to that game, the Cougars defeated Purdue by a score of 62-60 and Gonzaga by a score of 81-76. Houston has won 17 games in a row and they finished first in the Big 12 standings with a 19-1 record. Houston has scored 74 points per game and they have allowed 58.3 points against per game, while also averaging 36.7 rebounds and 12.3 assists per game this season. LJ Cryer is averaging 15.4 points, 2.3 rebounds, and 2.0 assists per game, while Emanuel Sharp is averaging 12.7 points, 3.0 rebounds, and 1.4 steals per game this year. Houston is shooting 45.8% from the field, 74.1% on free throws, and 39.8% on three pointers this season. 

Why Duke will beat Houston

• Duke has won each of its last 15 games.
• Duke has won the first half in 21 of its last 22 games against non-Conference opponents.

Total Points Facts

• Each of Duke’s last seven games against non-Conference opponents at neutral venues have produced a total of 142+ points.
• Each of Houston’s last six NCAA Tournament games against Top 4 seeds have produced a total of 132 or fewer points.

Matchup/League Facts

• Duke ranks 1st among Division 1 teams for point differential per game this season (+22.1).
• Duke ranks 1st among Division 1 teams for offensive rating this season (126.4).
• Houston ranks 1st among Division 1 teams for opponent points per game this season (58.1).
• Houston ranks 1st among Division 1 teams for opponent field goals made per game this season (19.4).

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Duke vs Houston Prediction 

Both of these teams come into this matchup on lengthy winning streaks and they absolutely dominated each of their conferences, so this should be a great game to watch. Houston isn’t elite offensively, but they are on defense, where they are allowing just 58.3 points against per game this year. Duke has scored at least 85 points in four straight games, so this will be Houston’s toughest test yet. The Blue Devils are also strong on defense, but they did allow 93 points to Arizona two games ago. Houston has to slow this pace down to a crawl if they want to have a chance, but I think Duke has too many options on offense to slow down. Take the Blue Devils here.