College Basketball Picks

Houston vs Gonzaga Prediction 3/22/25 College Basketball Picks Today

Gonzaga (26-8) vs. Houston (31-4)
March 22, 2025 8:40 pm EDT
The Line: Houston -4.5; Over/Under: 139.5
(Get latest betting odds)

The Gonzaga Bulldogs and the Houston Cougars meet Saturday in college basketball action from the INTRUST Bank Arena. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Gonzaga vs. Houston prediction.

Gonzaga Recap

The Gonzaga Bulldogs booked their spot in the Second Round of the NCAA Tournament after blowing out the Georgia Bulldogs by a final score of 89-68.


Bulldogs Looking For 10th Straight Sweet 16 Appearance

Graham Ike leads the Bulldogs in scoring and rebounding with 17 PPG and 7.4 RPG while Khalif Battle has 13.5 PPG with 3.6 RPG. Ryan Nembhard has 10.6 PPG with 3 RPG and a team-high 9.8 APG to lead the Zags in assists as well as 1.7 SPG to lead the way in steals as well. Braden Huff has 11 PPG with 3.4 RPG and Nolan Hickman has also chipped in 11.2 PPG and 2.3 RPG as well, rounding out the group of double-digit scorers for Gonzaga so far this season. Ben Gregg has also added 9.2 PPG with 5 RPG and Michael Ajayi has 6.6 PPG with 5.5 RPG as well this season. As a team, Gonzaga is averaging 86.6 PPG on 50% shooting from the field, 34.4% from three and 80.1% from the foul line this season.

Why the Gonzaga Bulldogs will win

  • Gonzaga has won each of its last eight night games.
  • Houston has lost four of its last five games against AP-ranked opponents at a neutral venue.

Houston Recap

The Houston Cougars punched their ticket to the Round of 32 with a 78-40 blowout win over SIU-Edwardsville last time out.

Cougars Hunting For Sixth Straight Sweet 16 Spot

L.J. Cryer leads the Cougars in scoring with 15.2 PPG while Emanuel Sharp has 12.5 PPG with 3.1 RPG. J’Wan Roberts has 10.7 PPG with a team-high 6.2 RPG to lead the Cougars on the glass up to this point in the year while Milos Uzan has added 11.6 PPG with 3 RPG and a team-high 4.3 APG to lead Houston in assists, rounding out the group of double-digit scorers for Houston so far this season. Terrance Arceneaux has 7.2 PPG with 2.9 RPG and Joseph Tugler’s added 5.4 PPG and 5.7 RPG. As a team, Houston’s averaging 74.2 PPG on 45.8% shooting from the field, 39.8% from three and 74.1% from the foul line this season.

Why the Houston Cougars will win

  • Houston has won each of its last 17 night games.
  • Gonzaga has lost each of its last four games against Top 5 AP-ranked opponents at a neutral venue.

Total Points Facts

  • Seventeen of Gonzaga’s last 18 NCAA Tournament games have produced a total of 142+ points.
  • Sixteen of Houston’s last 18 night games against non-Conference opponents have produced a total of 137 or fewer points.

Gonzaga vs. Houston Prediction

I’m on Houston here. I liked what I saw from Gonzaga in the first round, but that was against a Georgia team that’s had trouble making the step up in class on the road all season. Houston’s got a fantastic defense and I think that the defense for the Cougars shuts down Gonzaga here. The Zags obviously have the benefit of playing in the WCC, but I think that the Cougars provide a different kind of test that Gonzaga won’t be able to pass in this game. Give me Houston in this one.

Chris Ruffolo's Free Pick: Houston -4.5

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Chris Ruffolo

Chris joined the Sports Chat Place team in August 2016 and has a proven system that combines multiple analytical and situational statistics and trends to give out thousands of winning picks over the last three years with winning records across all of the top leagues, Follow Chris Ruffolo on Twitter @ruffthepickdawg

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