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Louisville vs Florida State Prediction 2/22/25 College Basketball Picks Today

Florida State (16-10) vs. Louisville (20-6)
February 22, 2025 12:00 pm EDT
The Line: Louisville -13.5; Over/Under: 150.5
(Get latest betting odds)

In this article, we will formulate a Louisville vs. Florida State Prediction for the college basketball game on Saturday, February 22nd, at the KFC Yum! Center. Let’s take a look at a Louisville Cardinals vs. Florida State Seminoles pick. 

These two teams faced off right before Christmas, and Louisville picked up the 90-76 victory. 


Why Aren’t More People Talking About Louisville?

Louisville is one of the best teams in the ACC, and because of substantial work in the transfer portal this offseason, I believe they can make a deep run in the NCAA tournament. Louisville has won four games in a row, and the offense has paced them to success. Two games ago, against NC State, they won 91-66; in the last game against Notre Dame, they came out in the top 75-60. Louisville shot 49.1 percent from the field and 33.3 percent from deep. All five starters finished with at least 10 points. Chucky Hepburn, one of the big offseason additions, led the team with 16 points, six assists, and two rebounds. 

The Cardinals have a 20-6 record overall, and they have gone 10-3 against the spread. Louisville has leaned on the offense all season, averaging 79.5 points, which is the 55th-best in college basketball. It’s clear the goal this offseason was to bring in three-point shooters, and the plan has worked as they are averaging 30.35 attempts per game, which is 5th in the league. Hepburn is averaging 15 points per game, shooting 44.1 percent from the field and 33.8 percent from behind the three-point line. 

Why Louisville Will Beat Florida

  • Louisville has won each of its last 10 games at KFC Yum! Center against non-AP-ranked opponents.
  • Florida State has lost seven of its last eight day games against the Atlantic Coast Conference.
  • Florida State has lost the first half in four of its last five road games.

Last Few Games for Leonard Hamilton with Florida State

With Leonard Hamilton retiring at the end of the season, this is the last few games he has been in charge of. After a slow start to the season, Florida State has been playing better, and they have won three of the last four games. Given that it’s been against lower competition in the ACC, they might fall into that category. Florida State faced off against Miami on Wednesday, and they picked up the 74-66 victory. The Seminoles used 43 points in the second half. Malique Ewin had a strong game, putting up 24 points, five rebounds, and two assists. 

Florida State has a 16-10 overall record, but it has only two wins on the road. The defense has been inconsistent, but the offense has been making up for it lately. Florida State is averaging 75.3 points per game. They have also done a good job of getting to the free-throw line, averaging 16.58 free throws per game. Jamir Watkins is having a tremendous season, averaging 17.9 points while shooting 42.2 percent from the field and 33.3 percent from behind the three-point line. 

Why Florida State Will Beat Louisville

  • Louisville has lost eight of its last 10 home day games against the Atlantic Coast Conference.
  • Florida State has won four of its last five day games against Louisville.
  • The road team has won the first half in four of Louisville’s last five games.

Louisville vs Florida State Prediction

The first game between these two teams had 90 points scored by Louisville, and there is no reason they can’t get close to that number again here. Florida State’s offense has been playing with all kinds of confidence, and the Seminoles are averaging 75.3 points per game. Three of the last four games played between this game have gone over. Louisville will be making those shots from deep, and that will be enough for this game to be a shootout. If nothing else, this should be entertaining if games, where zero defense is played, are up your alley. Back the over to cash.

Shane Mickle's Free Pick: Over

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Shane Mickle

Sports is about all Shane knows in this life! He has a passion for sports and writing, which makes working for Sportschatplace a perfect job for him! If you find him cheering for a team it's usually a Minnesota team, or the Kansas Jayhawks!

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