Louisville vs Indiana Prediction 12/6/25 College Basketball Picks Today

In this article, we will formulate a Louisville vs Indiana Prediction for this College Basketball game on Saturday, December 6^th. Let’s take a look at the prediction for this College Basketball matchup.

Indiana Hoosiers Preview

Indiana has a 7-1 record this season and is sitting on the 4th place of the Big Ten conference. They have a 6-0 home record and a 0-0 away record and is coming off a 73-64 away loss against Minnesota. Their previous two games were a win against Bethune-Cookman and a win against Kansas State.

Offensively, Indiana averages 89.6 points per game, while allowing 62.4 points per game defensively. The Hoosiers shoot with 50.4% from the field (15th), and with 37.8% from beyond the arc (28th). They shoot with 76.8% from the free throw line (33rd), and grab 39.3 rebounds per game (52nd), while dishing out 20.9 assists per game (2nd) and committing 9.7 turnovers per game (47th).

Tucker DeVries leads Indiana in scoring, with an average of 16.8 points per game. Tayton Conerway adds 12.6 points per game and a team-high 4.9 assists per game. Sam Alexis adds 10.5 points per game and a team-high 6 rebounds per game.

Louisville Cardinals Preview

Louisville has a 7-1 record this season and is sitting on the 2nd place of the Atlantic Coast conference. They have a 6-0 home record and a 1-0 away record and is coming off a 89-80 away loss against Arkansas. Their previous two games were a win against NJIT and a win against Eastern Michigan.

Offensively, Louisville averages 96.7 points per game, while allowing 63 points per game defensively. The Cardinals shoot with 48.1% from the field (43rd), and with 37.3% from beyond the arc (35th). They shoot with 75.8% from the free throw line (49th), and grab 46.0 rebounds per game (9th), while dishing out 20.7 assists per game (3rd) and committing 10.6 turnovers per game (89th).

Ryan Conwell leads Louisville in scoring, with an average of 19.5 points per game. Mikel Brown Jr. adds 17.6 points per game and a team-high 5.6 assists per game. Sananda Fru adds 10.4 points per game and a team-high 6.1 rebounds per game.

Louisville Cardinals @ Indiana Hoosiers Betting Trends: December 6, 2025

Why the Indiana Hoosiers will win

• Indiana has won each of its last 12 games against non-Conference opponents.
• Louisville has lost 16 of its last 17 day games against AP-ranked opponents.
• Indiana has won the first half in each of its last 12 games against non-Conference opponents.

Why the Louisville Cardinals will win

• Indiana has lost each of its last seven games against AP-ranked opponents at a neutral venue.
• Louisville has won 28 of its last 32 games.
• Indiana has lost the first half in 14 of its last 15 games against AP-ranked opponents at a neutral venue.

Total Points Facts

• Forty-four of Louisville’s last 46 day games against AP-ranked opponents have produced a total of 158 or fewer points.
• Each of Indiana’s last nine day games against the Atlantic Coast Conference have produced a total of 157 or fewer points.

Louisville vs Indiana Prediction

In this Louisville vs Indiana Prediction, Louisville is coming as -5.5 road favorites. Both teams have been excellent this season and have an identical overall record with just one defeat in their 8 games played. They are also both 5-3 against the spread this season, so I see no value on either side. Both teams combined elite offenses with elite defenses, but they have been playing some lower-scoring games lately, as they are 7-2 to the under in their last 9 games combined. With defense proving stronger for both of those two teams lately, I expect another low-scoring affair, so take the under 161.5 points.