Louisville vs Jackson State Prediction 11/6/25 College Basketball Picks Today

The Jackson State Tigers and the Louisville Cardinals meet Thursday in college basketball action from the KFC Yum! Center. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Jackson State Tigers vs. Louisville Cardinals prediction.

Jackson State Tigers Recap

The Jackson State Tigers come into this game looking to rebound from a 113-55 loss at the hands of Illinois last time out to sit at 0-1 on the year.

Tigers Looking For Massive Upset For First Win

Devin Ree led the Tigers with 19 points on 7 of 11 shooting with 4 threes and a pair of steals while Daeshun Ruffin added 12 points with 5 rebounds as the only other double-digit scorer for Jackson State so far this season. Mike Williams added 9 points with a pair of steals while Dorian McMillian added a team-high 3 assists and a pair of steals despite shooting 0 for 9 from the floor. 

Why the Jackson State Tigers will win

• Jackson State has won each of its last four games following a road loss.

Louisville Cardinals Recap

The Louisville Cardinals come into this game looking to add on to their 104-45 blowout win over South Carolina State last time out to sit at 1-0 this season.

Cardinals Looking For Another Confident Win

Khani Rooths led the Cardinals with 20 points including 7 rebounds and 3 assists while Isaac McKneely added 17 points with 4 rebounds on 6 of 13 shooting with 5 threes. J’Vonne Hadley added 13 points with a team-high 9 rebounds and a pair of steals while Ryan Conwell added 12 points iwth 3 rebounds, 2 assists and 2 steals. Mikel Brown added 11 points on 4 of 6 shooting with a team-high 6 assists to cap off Louisville’s scoring in double figures in the win while Sananda Fru chipped in 9 points with a team-high 8 rebounds as well for the Cardinals as well in the win.

Why the Louisville Cardinals will win

• Jackson State has lost each of its last 16 games against non-Conference opponents.
• Louisville has won each of its last 15 games at KFC Yum! Center against non-AP-ranked opponents.

Total Points Facts

• Each of Louisville’s last 11 night games have produced a total of 157 or fewer points.
• Each of Jackson State’s last 12 Thursday games against non-Conference opponents have produced a total of 151 or fewer points.

Jackson State Tigers vs. Louisville Cardinals Prediction

I’m on Louisville here. I get the case to be made from either side in this game just given the size of this number, but I think that the Cardinals are still the better team by a mile and a half in this game. It’s just a matter of Louisville naming their number in this spot. The Cardinals run away with this one here. Give me Louisville.