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Michigan vs St. Louis Prediction 3/21/26 College Basketball Picks Today

St. Louis (29-5) vs. Michigan (32-3)
March 21, 2026 12:10 pm EDT
The Line: Michigan -12.5; Over/Under: 161.5
(Get latest betting odds)

The Saint Louis Billikens and Michigan Wolverines meet Saturday in the college basketball NCAA Tournament at the KeyBank Center. Here’s a Michigan vs. St. Louis Prediction. This article will include a Michigan vs. St. Louis Pick.

Saint Louis Billikens Betting Preview

The Saint Louis Billikens beat Georgia and lost to Dayton. Saint Louis has won 10 of its last 14 games.

The Saint Louis Billikens are averaging 87.8 points on 51.3 percent shooting and allowing 69.2 points on 37.9 percent shooting. Robbie Avila is averaging 12.9 points and 4.6 rebounds, while Dion Brown is averaging 11.3 points and 1.6 assists. Trey Green is the third double-digit scorer and Amari McCottry is grabbing 5.3 rebounds. The Saint Louis Billikens are shooting 40.5 percent from beyond the arc and 73.3 percent from the free throw line. The Saint Louis Billikens are allowing 29.1 percent shooting from deep and are grabbing 36.9 rebounds per game.

Michigan Wolverines Betting Preview

The Michigan Wolverines beat Howard and lost to Purdue. Michigan has won 18 of its last 20 games.

The Michigan Wolverines are averaging 88.5 points on 51 percent shooting and allowing 69.1 points on 38 percent shooting. Yaxel Lendeborg is averaging 14.4 points and 3.3 assists, while Morez Johnson Jr. is averaging 13.4 points and 7.3 rebounds. Aday Mara is the third double-digit scorer and Elliot Cadeau is grabbing 2.5 rebounds. The Michigan Wolverines are shooting 36.5 percent from beyond the arc and 74.5 percent from the free throw line. The Michigan Wolverines are allowing 29.6 percent shooting from deep and are grabbing 37.1 rebounds per game.

Why the Michigan Wolverines will win

  • Saint Louis has lost each of its last 19 games against AP-ranked opponents.
  • Michigan has won each of its last 12 games against non-AP-ranked opponents.
  • Michigan has won the first half in each of its last 13 day games against non-AP-ranked opponents at a neutral venue.

Why the Saint Louis Billikens will win

  • Saint Louis has won 12 of its last 13 games against non-Conference opponents.
  • Michigan has lost three of its last four day games against non-AP-ranked opponents at a neutral venue.
  • Saint Louis has won the first half in each of its last seven games against non-Conference opponents.

Total Points Facts

  • Each of Michigan’s last 11 day games against non-AP-ranked opponents at a neutral venue has produced a total of 159 or fewer points.
  • Forty-seven of Saint Louis’ last 52 games at a neutral venue have produced a total of 161 or fewer points.

Matchup/League Facts

  • Michigan is one of only two teams to reach the Sweet 16 in each of its last five NCAA Tournament appearances.
  • Michigan ranks 2nd among Division 1 teams for opponent field goal percentage this season (38.0%).
  • Saint Louis ranks 1st among Division 1 teams for opponent field goal percentage this season (37.9%).
  • Saint Louis has recorded the equal-longest winning streak among Division 1 teams this season (18 games).

Michigan vs St. Louis Prediction

Michigan is going to be big favorites because of the name, the conference and everything that comes with it, but it also hasn’t covered a number since February 27. Michigan is 1-8 ATS in its last 9 games as a favorite overall and 2-13 ATS in its last 15 games as a double-digit favorite.

Saint Louis is an experienced team that can score with the best of them and also defends at an above-average level. Even against michigan, at his height, Avila can be the best player on the court. The Billikens are a good team and I’m not excited to leave this many points on the table. Dangerous game for the Wolverines if there’s any sort of slip-up at either end of the court. Give me the points.

Randy Chambers's Free Pick: St. Louis +12.5

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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