Notre Dame vs Louisville Prediction 2/4/26 College Basketball Picks Today

In this article, we will formulate a Notre Dame vs Louisville Prediction for this college basketball game on Wednesday, February 4^th. Let’s take a look at the prediction for this college basketball matchup.

Louisville Cardinals Preview

The Louisville Cardinals have a 15-6 overall record this season and a 5-4 record in the ACC. They are coming off an 88-74 home win against SMU and their previous three games were an 83-52 away loss against Duke, an 85-71 home win against Virginia Tech and a 100-59 away win against Pittsburgh.

Offensively, Louisville averages 86.1 points per game, while allowing 70.5 points per game defensively. The Cardinals shoot with 46% from the field and grab 40.4 rebounds per game, while dishing out 17.6 assists per game. They average 3.3 blocks per game and 7.3 steals per game defensively.

Ryan Conwell leads Louisville in scoring, with an average of 19.1 points per game, while shooting with 39.9% from the field and 83.1% from the free throw line. Sananda Fru leads the team in rebounds with 6.7 per game. Aly Khalifa leads the team in assists with 2.8 per game.

Notre Dame Fighting Irish Preview

The Notre Dame Fighting Irish have an 11-11 overall record this season and a 2-7 record in the ACC. They are coming off an 86-72 away loss against Syracuse and their previous three games were a 100-97 home loss in double overtime against Virginia, a 68-64 home win against Boston College and a 91-69 away loss against North Carolina.

Offensively, Notre Dame averages 74 points per game, while allowing 72.2 points per game defensively. The Fighting Irish shoot with 45% from the field and grab 37.1 rebounds per game, while dishing out 12.0 assists per game. They average 2.1 blocks per game and 4.3 steals per game defensively.

Jalen Haralson leads Notre Dame in both scoring and assists, with an average of 15.5 points and 2.6 assists per game, while shooting with 50.4% from the field and 63.3% from the free throw line. Carson Towt leads the team in rebounds with 9.5 per game.

Notre Dame Fighting Irish @ Louisville Cardinals Betting Trends: February 4, 2026

Why the Louisville Cardinals will win

• Louisville has won each of its last 33 games as an AP-ranked team against a non-AP-ranked team at KFC Yum! Center.
• Notre Dame has lost each of its last 12 games against AP-ranked opponents.
• Louisville has won the first half in each of its last nine night games at KFC Yum! Center against non-AP-ranked opponents.

Why the Notre Dame Fighting Irish will win

• Notre Dame has won four of its last five games against Louisville.
• Louisville has lost four of its last five games following a home win.
• Notre Dame has won the first half in three of its last four games against Louisville.

Total Points Facts

• Each of the last nine games between Notre Dame and Louisville have produced a total of 152 or fewer points.
• Thirty-one of Notre Dame’s last 36 night games against Conference opponents have produced a total of 151 or fewer points.

Matchup/League Facts

• Louisville ranks 4th among Division 1 teams for three-point field goal attempts per game this season (33.9).
• Louisville ranks 5th among Division 1 teams for three-point field goals made per game this season (11.8).
• Notre Dame ranks 363rd among Division 1 teams for steals per game this season (4.3).

Notre Dame vs Louisville Prediction

In this Notre Dame vs Louisville Prediction, Louisville is coming as -17.5 home favorites. Louisville has been the better team this season and have been very strong at home. They are 3-1 in their last 4 games but 2-6 against the spread, but are facing a struggling Notre Dame squad that has won only once in its last eight games played and is 1-6 against the spread in its last 7. Louisville has been better both offensively and defensively, having a +15.5 point differential this season and I expect them to get the job done at home against a struggling Notre Dame squad. Take Louisville and lay the big number at home.