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St. John’s vs Creighton Prediction 2/21/26 College Basketball Picks Today

Creighton (14-13) vs. St. John's (21-5)
February 21, 2026 12:00 pm EDT
The Line: St. John's -12.5; Over/Under: 154.5
(Get latest betting odds)

The Creighton Bluejays and St. John’s Red Storm meet Saturday in college basketball action at Madison Square Garden. Here’s a St. John’s vs Creighton Prediction. This article will include a St. John’s vs Creighton Pick.

Creighton Bluejays Betting Preview

The Creighton Bluejays lost to Villanova, beat UConn, and they play DePaul next. Creighton has lost 5 of its last 7 games.

The Creighton Bluejays are averaging 76.6 points on 45.8 percent shooting and allowing 75.5 points on 45.4 percent shooting. Josh Dix is averaging 12.3 points and 3.8 rebounds, while Austin Swartz is averaging 11.4 points and 2.7 rebounds. Jasen Green is the third double-digit scorer and Nik Graves is grabbing 3.1 rebounds. The Creighton Bluejays are shooting 35.1 percent from beyond the arc and 75.2 percent from the free throw line. The Creighton Bluejays are allowing 35.6 percent shooting from deep and are grabbing 32.1 rebounds per game.

St. John’s Red Storm Betting Preview

The St. John’s Red Storm beat Providence and Marquette, and they play UConn next. St. John’s hasn’t lost a game since January 3.

The St. John’s Red Storm are averaging 84 points on 45.9 percent shooting and allowing 72 points on 42.4 percent shooting. Zuby Ejiofor is averaging 16 points and 7.3 rebounds, while Bryce Hopkins is averaging 14 points and 2.2 assists. Oziyah Sellers is the third double-digit scorer and Ian Jackson is dishing 1.3 assists. The St. John’s Red Storm are shooting 34.5 percent from beyond the arc and 72.3 percent from the free throw line. The St. John’s Red Storm are allowing 32.8 percent shooting from deep and are grabbing 35 rebounds per game.

Why the St. John’s Red Storm will win

  • St. John’s has won each of its last 12 games.
  • Creighton has lost each of its last four games against AP-ranked opponents at Madison Square Garden.
  • St. John’s has won the first half in each of its last 13 day games against Conference opponents at Madison Square Garden.

Why the Creighton Bluejays will win

  • Creighton has won eight of its last nine day games following a road win.
  • Creighton has won the first half in 11 of its last 13 day games against AP-ranked opponents.

Total Points Facts

  • Twenty-two of Creighton’s last 24 games at Madison Square Garden have produced a total of 154 or fewer points.
  • Each of St. John’s’ last four home games against Creighton have produced a total of 152 or fewer points.

St. John’s vs Creighton Prediction

St. John’s has the ability to blow this game out of the water, but it’s also a look-ahead spot with UConn on deck. St. John’s is also just 13-13 ATS on the season, so this team isn’t making you money. Creighton has underachieved this season, but it’s fresh off an outright win over UConn, the sort of win that potentially turned the season around. We know the talent is there for Creighton; it’s about putting it together.

That win could do wonders for Creighton down the stretch. Early start, which could lead to some sluggish play early. Creighton has a chance to settle in early. This could be a competitive game. Give me the points. 

Randy Chambers's Free Pick: Creighton +12.5

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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