Buffalo vs Ohio Prediction Football Picks Today 11/28/25
Ohio Bobcats (7-4) vs. Buffalo Bulls (5-6)
November 28, 2025 12:00 pm EDT
The Line: Buffalo Bulls 7 / Ohio Bobcats -7; Over/Under: 44.5
(Get latest betting odds)
The Ohio Bobcats and Buffalo Bulls meet Friday in college football action at UB Stadium. Here’s a Buffalo vs Ohio Prediction. This article will include a Buffalo vs Ohio Pick.
Ohio Bobcats Betting Preview
The Ohio Bobcats beat UMass and lost to Western Michigan. Ohio has won 6 of its last 8 games. Parker Navarro is completing 63 percent of his passes for 2,085 yards, 12 touchdowns, and 9 interceptions. Rodney Harris II and Chase Hendricks have combined for 1,222 receiving yards and 8 touchdowns, while Mason Williams has 24 receptions.
The Ohio Bobcats ground game is averaging 238.6 yards per contest, and Sieh Bangura leads the way with 1,123 yards and 13 touchdowns. Defensively, Ohio is allowing 23.5 points and 392.6 yards per game. Jalen Thomeson leads the Ohio Bobcats with 73 tackles, Jay Crable has 5 sacks and Cameron Hollobaugh has 2 interceptions.
Buffalo Bulls Betting Preview
The Buffalo Bulls lost to Central Michigan and Miami OH. Buffalo has lost 3 of its last 4 games. Ta’Quan Roberson is completing 57.8 percent of his passes for 2,250 yards, 15 touchdowns, and 11 interceptions. Victor Snow and Nik McMillan have combined for 1,592 receiving yards and 11 touchdowns, while Jasaiah Gathings has 34 receptions.
The Buffalo Bulls ground game is averaging 150.1 yards per contest, and Al-Jay Henderson leads the way with 724 yards and 5 touchdowns. Defensively, Buffalo is allowing 25.1 points and 361.7 yards per game. Red Murdock leads the Buffalo Bulls with 128 tackles, Junior Poyser has 5.5 sacks and Jalen McNair has 2 interceptions.
Why the Buffalo Bulls will win
- The home team has won 10 of Ohio’s last 11 games.
- Ohio has lost four of its last five road games.
- Ohio has failed to cover the spread in each of its last four road games.
- The home team has covered the spread in six of Ohio’s last seven games.
Why the Ohio Bobcats will win
- Ohio has won each of its last 11 November games as a favorite.
- Buffalo has lost four of its last five home games.
- Buffalo has failed to cover the spread in eight of its last nine games.
- Ohio has covered the spread in each of its last four games against Buffalo.
- Ohio has won the first half in seven of its last nine games against conference opponents.
Total Points Facts
- Each of Ohio’s last six road games in November have gone UNDER the total points line.
- Each of Buffalo’s last four home games against Ohio have gone UNDER the total points line.
Buffalo Bulls Player Prop Facts
- Nik McMillan has recorded 100+ receiving yards in five consecutive games – longest streak in the FBS, heading into Week 14.
Ohio Bobcats Player Prop Facts
- Heading into Week 14, Sieh Bangura ranks 10th amongst FBS players for rushing yards (1123) this season.
Matchup/League Facts
- Buffalo ranks 4th among FBS teams for Q1 opponent points per game this season (2.2).
- Buffalo ranks T125th among FBS teams for Q4 points per game this season (4.0).
- Ohio ranks 15th among FBS teams for rushing yards per game this season (217.3).
- Ohio ranks T20th among FBS teams for Q2 opponent points per game this season (5.0).
Buffalo vs Ohio Prediction
Ohio is the better team that’s closing in on a MAC Championship berth, but this is a lot of points for a subpar team overall. Ohio is 85th in scoring offense and has issues stopping the run. Buffalo is awful offensively and has lost 3 of its last 4 games, but it’s also a win away from clinching a bowl berth. It’s also senior night for a Buffalo team that has 30 seniors. Ohio has failed to cover 5 of its last 8 games as a favorite, and has outright lost once against Ball State. Ohio is 1-4 SU on the road this season. I’ll grab the free touchdown with Buffalo.