College Football

California vs Clemson Prediction Football Picks Today 9/25/26

Clemson Tigers (2-1) vs. California Golden Bears (2-1)
September 25, 2026 10:30 pm EDT
The Line: California Golden Bears +1.5 / Clemson Tigers -1.5; Over/Under: 50.5
(Get latest betting odds)

The Clemson Tigers and the Cal Golden Bears meet in week 4 college football action from Memorial Stadium on Friday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Clemson Tigers vs. Cal Golden Bears Prediction.

Clemson Tigers Recap

The Clemson Tigers come into this game looking to add on to their 28-20 win over North Carolina last time out to improve to 2-1 this season. After this game, Clemson will head home for a game against Miami.

Tigers Win Back-To-Back Games

Tait Reynolds has thrown for 415 yards, 1 touchdown and 1 interception on 64.5% passing while Gideon Davidson leads Clemson in rushing with 187 rushing yards and 1 touchdown so far this season. Reynolds sits behind Davidson on the ground with 55 yards and 0 TDs. T.J. Moore leads the Tigers in receiving with 172 yards on 18 catches along with 1 touchdown, while Bryant Wesco Jr. trails with 141 yards on 13 catches. On defense, Corey Myrick has a team-high 27 total tackles while Will Heldt leads the team with 4 sacks, and Clemson’s defense as a whole has combined for 6 sacks and 2 interceptions so far this season.

Cal Golden Bears Recap

The Cal Golden Bears come into this game looking to build on their 45-7 win over Wagner last time out to sit at 2-1 this season. After this game, Cal will head on the road for a game against UNLV.

Bears Win Two In A Row

Jaron-Keawe Sagapolutele has thrown for 866 yards, 7 touchdowns and 2 interceptions on 66.7% passing while Adam Mohammed leads Cal in rushing with 285 rushing yards and 3 touchdowns so far this season. Ashten Emory sits behind Mohammed on the ground with 24 yards and 1 TD. Ian Strong leads California in receiving with 206 yards on 14 catches, while Chase Hendricks trails closely with 195 yards on 20 catches along with 2 touchdowns. On defense, Kingston Lopa has a team-high 17 total tackles and leads the team with 5 interceptions, while Nate Burrell and Solomon Williams each have 1 sack. Cal’s defense as a whole has combined for 5 sacks and 5 interceptions so far this season.

Clemson Tigers @ California Golden Bears Betting Trends: Week 4

 

Why the California Golden Bears will win

  • California has won three of its last four September games as an underdog.
  • Clemson has lost three of its last four road games in September.
  • California has covered the spread in 10 of its last 12 September games as an underdog against non-AP-ranked teams.
  • Clemson has failed to cover the spread in five of its last six games in September.
  • Clemson has lost the first half in five of its last six games in September.
  • California has won the first quarter in five of its last six home games against non-AP-ranked teams.

Why the Clemson Tigers will win

  • Clemson has won 39 of its last 46 games in September.
  • California has failed to cover the spread in seven of its last eight games against non-AP-ranked teams.
  • Clemson has covered the spread in four of its last five road games.
  • Clemson has won the first half in 45 of its last 53 September games as a favorite.

Total Points Facts

  • Seven of Clemson’s last eight road games against non-AP-ranked teams have gone UNDER the total points line.
  • Eleven of California’s last 13 September games against non-AP-ranked teams have gone UNDER the total points line.

California Golden Bears Player Prop Facts

  • Heading into Week 4, Kingston Lopa ranks 1st amongst FBS players for interceptions (5) this season.

Clemson Tigers Player Prop Facts

  • Heading into Week 4, Nolan Hauser ranks 1st amongst FBS players for made field goals (9) this season.

Matchup/League Facts

  • California has the worst single-game yard differential in a win this season (249-437 vs Syracuse in Week 2).
  • California ranks T5th among FBS teams for interceptions this season (5).
  • Clemson ranks T1st among FBS teams for 4th down conversion percentage this season (100.0).
  • Clemson ranks T136th among FBS teams for 3rd down conversion percentage this season (20.0).

Clemson Tigers vs. Cal Golden Bears Prediction

I’m on the Bears at home here. Clemson’s coming off of a much-needed win but in fairness it’s a win they probably didn’t deserve and I like what I’ve seen from Cal. I can’t remember the last time Clemson had to make a cross country trip like this and I think Cal scraps their way to a win here. Give me Cal.

Chris Ruffolo's Free Pick: California Golden Bears +1.5

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Chris Ruffolo

Chris joined the Sports Chat Place team in August 2016 and has a proven system that combines multiple analytical and situational statistics and trends to give out thousands of winning picks over the last three years with winning records across all of the top leagues, Follow Chris Ruffolo on Twitter @ruffthepickdawg

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