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California vs San Diego State Prediction 9/20/25 College Football Picks Today

California vs San Diego State
September 20, 2025 10:30 pm EDT
The Line: California -12 / Over/Under: 47.5
(Get latest betting odds)

In this article, we will formulate a California vs San Diego State Prediction for this College Football Week 4 game on Saturday, September 20th at the Snapdragon Stadium. Let’s take a look at the prediction for this College Football matchup.

San Diego State Preview

San Diego State has a 1-1 record this season and are coming off a 13-36 road defeat in Washington State. Offensively, the Aztecs average 27.5 points per game, which ranks 78th in the nation. Defensively, they allow 18.0 points per game, which ranks 50th in the nation. San Diego State averages 339.5 total yards per game, with 155.0 rushing yards and 184.5 passing yards per game. They allow 245.5 total yards per game, 94.0 of them rushing and 151.5 passing yards per game.

Jayden Denegal leads the Aztecs with 28/55 completed passes and 340 total passing yards. He also adds -12 rushing yards and 1 touchdown. Lucky Sutton leads the team in rushing yards, with 188 and 2 touchdowns, while Christian Washington adds 49 rushing yards and 1 touchdown. Jordan Napier has a team-high 10 caught passes for a team-high 108 receiving yards, and has 1 touchdown. Wayne McCutcheon has caught 8 passes for 74 yards.

Defensively, Tano Letuli has a team-high 20 total tackles, 6 of them solo. August Salvati leads the Aztecs in sacks, with 1.5, while San Diego State had no interception in the game.

California Preview

California has a 3-0 record this season and are coming off a 27-14 home victory over Minnesota. Offensively, California averages 32.0 points per game, which ranks 60th in the nation. Defensively, they allow 10.7 points per game, which ranks 19th in the nation. California averages 387.7 total yards per game, with 118.7 rushing yards and 269.0 passing yards per game. They allow 280.0 total yards per game, 82.3 of them rushing and 197.7 passing yards per game.

Jaron-Keawe Sagapolutele leads California with 71/106 completed passes and 780 total passing yards. He also adds 22 rushing yards and 1 touchdown. Kendrick Raphael leads the team in rushing yards, with 201 and 1 touchdown, while Brandon High adds 80 rushing yards and 1 touchdown. Jacob De Jesus has a team-high 17 caught passes for a team-high 149 receiving yards, and has 1 touchdown. Mason Mini has caught 13 passes for 99 yards, and 2 touchdowns.

Defensively, Luke Ferrelli has a team-high 27 total tackles, 8 of them solo. Hezekiah Masses adds 14 total tackles, 8 of them solo and 3 interceptions. TJ Bush leads California in sacks, with 2, while Hezekiah Masses has a team-high 3 interceptions.

California vs San Diego State Prediction

In their previous meeting last season, California won 31-10 at home, covering the spread, as the game went under the point total. California is 2-1 in their three meetings against San Diego State, with each team winning at home. California has covered the spread in all three matches, and under is 2-1.

In this California vs San Diego State Prediction, California is coming as -12-point road favorites. Both teams are coming off opposite outcomes in their previous games, and California is undefeated so far this season. They have won and covered their only road game so far, and destroyed San Diego State last season by 21 points. They are outscoring their opponents by almost 22 points this season, and I like them as road favorites in this spot. Take California and lay the -12 points on the road.

Nikos Lagouretos's Free Pick: California -12

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