Clemson vs Georgia Southern Prediction Football Picks Today 9/12/26

In this article we will formulate a Clemson vs Georgia Southern prediction for this College Football game on Saturday, September 12th at Memorial Stadium in Clemson, South Carolina. Let’s take a look at the prediction for this Week 2 matchup. 

Clemson Tigers Betting Preview

The Clemson Tigers are 0-1 this year after they lost to LSU by a score of 51-10 last Saturday. Clemson led 3-0 early in the game, but they trailed 31-3 at halftime and allowed 20 more points in the second half for the ugly loss. The Tigers were out gained by a total of 644-145, went 1-13 on third downs, and tied the turnover battle at one in the game. Christopher Vizzina threw for 83 yards and one interception, while TJ Moore caught four passes for 31 yards. Jarvis Green rushed four times for 21 yards in the loss. 

The Tigers were 7-6 (4-4) last year and they finished tied for seventh in the ACC standings with four other teams. Clemson started the year with that loss to LSU, but bounced back with a 27-16 win over Troy. The Tigers were just 3-5 through eight games, but they won their last four regular season games. Clemson did make the Pinstripe Bowl, where they lost to Penn State by a score of 22-10. The Tigers scored 27.2 points per game in 2025, while they allowed 20.5 points against per game on defense. 

Georgia Southern Eagles Betting Preview

The Georgia Southern Eagles are 1-0 this season after they defeated Charleston Southern by a score of 31-0 in week one. Georgia Southern led 24-0 at halftime and they picked up the shutout victory with a low scoring second half. The Eagles out gained their opponent by a total of 513-117, went 5-13 on third downs, and won the turnover battle by a total of 2-1 in the game. Max Johnson threw for 281 yards and one touchdown, while Ashton Hollins caught eight passes for 106 yards and one touchdown. Jamarian Samuel rushed four times for 46 yards and one score in the game. 

Last season, Georgia Southern went 7-6 (4-4) and they finished fourth in the Sun Belt East standings. Georgia Southern started the year with a 42-14 loss to Fresno State and lost to USC 59-20 in their second game. The Eagles were just 3-5 through eight games, but they won four of their last five, including a 29-10 win over App State in the Birmingham Bowl. 

Why the Clemson Tigers will win

• Clemson has won 33 of its last 36 games against non-conference opponents at Memorial Stadium (Clemson).
• Georgia Southern has lost nine of its last 10 road openers as an underdog.
• Georgia Southern has failed to cover the spread in five of its last six September games as an underdog.
• The favorite has covered the spread in four of Georgia Southern’s last five games.
• Clemson has won the first quarter in 14 of its last 17 games against non-conference opponents at Memorial Stadium (Clemson).
• Clemson has won the first half in 33 of its last 35 games against non-conference opponents at Memorial Stadium (Clemson).

Why the Georgia Southern Eagles will win

• Georgia Southern has won each of its last six games against teams from South Carolina.
• Clemson has lost each of its last three games in September.
• Georgia Southern has covered the spread in each of its last seven games against teams from South Carolina.
• Clemson has failed to cover the spread in 10 of its last 11 games at Memorial Stadium (Clemson).
• Georgia Southern has won the first half in each of its last six games against teams from South Carolina.
• Georgia Southern has won the first quarter in each of its last four games against teams from South Carolina.

Total Points Facts

• Each of Georgia Southern’s last four games have gone UNDER the total points line.
• Five of Clemson’s last six games against opponents from the Sun Belt Conference have gone UNDER the total points line.

Clemson Tigers Player Prop Facts

• Heading into Week 2, Tyler Brown ranks T1st amongst qualified players for catch rate (100.0%) this season.

Georgia Southern Eagles Player Prop Facts

• Heading into Week 2, Terrance Gibbs ranks T1st amongst qualified players for catch rate (100.0%) this season.

Matchup/League Facts

• Clemson ranks T1st among FBS teams for red zone percentage this season (100.0).
• Clemson ranks 135th among FBS teams for yards per game this season (145.0).
• Georgia Southern ranks T1st among FBS teams for points allowed per game this season (0.0).
• Georgia Southern ranks T1st among FBS teams for Q1 opponent points per game this season (0.0).

Clemson vs Georgia Southern Prediction 

Clemson was absolutely dominated by LSU in week one, so they will look to bounce back with a win here. The Tigers couldn’t do anything on either side of the ball, but LSU also has elite talent. Georgia Southern picked up a shutout win over a FCS school and Max Johnson has plenty of experience at quarterback. I did not like what I saw from Clemson last week, but I think they will be ready to go for this one, especially with it being a night game. Take the Tigers to cover here.