Clemson vs Louisville Prediction 11/14/25 College Football Picks Today

In this article, we will formulate a Clemson vs Louisville Prediction for this College Football Week 12 game on Friday, November 14^th. Let’s take a look at the prediction for this College Football matchup.

Louisville Cardinals Preview

Louisville has a 7-2 record this season and is sitting 6th in the ACC. They are 3-6 ATS, 5-4 in Over/Under and have a 4-2 home record and a 3-0 away record. Louisville is coming off a 26-29 home loss against California and will face SMU and Kentucky next.

Offensively, Louisville averages 32.9 points per game, ranking 35th in the nation, while defensively, they allow 21.7 points per game, which is 41st. Louisville averages 401.4 total yards per game (246.6 passing and 154.9 rushing), while allowing 296.8 total yards per game (108.7 rushing and 188.1 passing).

Miller Moss leads Louisville with 2,132 passing yards with 63.8% completed passes and 11 touchdowns. Isaac Brown leads the team in rushing yards with 782, while Chris Bell has a team-high 62 receptions for 792 receiving yards. Defensively, TJ Quinn has a team-high 67 total tackles (28 of them solo), while Wesley Bailey leads the team in sacks, with 5, and Antonio Watts has a team-high 3 interceptions.

Clemson Tigers Preview

Clemson has a 4-5 record this season and is sitting 10th in the ACC. They are 3-6 ATS, 4-5 in Over/Under and have a 2-4 home record and a 2-1 away record. Clemson is coming off a 24-10 home win against Florida State and will face Furman next.

Offensively, Clemson averages 28.4 points per game, ranking 68th in the nation, while defensively, they allow 25.2 points per game, which is 73rd. Clemson averages 409.3 total yards per game (288.4 passing and 120.9 rushing), while allowing 351.3 total yards per game (106.2 rushing and 245.1 passing).

Cade Klubnik leads Clemson with 2,136 passing yards with 67.9% completed passes and 14 touchdowns. Adam Randall leads the team in rushing yards with 570, while Bryant Wesco Jr. has a team-high 31 receptions for 537 receiving yards. Defensively, Sammy Brown has a team-high 67 total tackles (37 of them solo), while Will Heldt leads the team in sacks, with 5, and Ricardo Jones has a team-high 4 interceptions.

Clemson Tigers @ Louisville Cardinals Betting Trends: Week 12

Louisville Cardinals Player Prop Facts

• Heading into Week 12, Isaac Brown ranks 1st amongst qualified players for Yards Per Carry (8.6) this season.

Clemson Tigers Player Prop Facts

• Heading into Week 12, Ricardo Jones ranks T8th amongst FBS players for interceptions (4) this season.

Matchup/League Facts

• Louisville ranks T7th among FBS teams for interceptions this season (12).
• Louisville is one of only nine FBS teams undefeated in road games this season (3-0).
• Clemson ranks 15th among FBS teams for passing yards per game this season (288.4).
• Clemson ranks 19th among FBS teams for rushing yards allowed per game this season (106.2).

Clemson vs Louisville Prediction

In this Clemson vs Louisville Prediction, Louisville is coming as -3.5 point home favorites, with the total set at 51.5 points. Louisville has a better overall record and are 3-1 in its last 4 games, while Clemson is 1-2 in its last 3. The Cardinals are better both offensively and defensively, winning by an average of 11.2 points per game, as they rank on the top-41 of the nation in both categories. I like Louisville as a small home favorite in this spot, so take Louisville and lay the -3.5 points in this one.