Wyoming Cowboys (2-1) vs. Colorado Buffaloes (1-2)
September 20, 2025 10:15 pm EDT
The Line: Colorado Buffaloes -13 / Wyoming Cowboys 13; Over/Under: 44.5
(Get latest betting odds)
The Wyoming Cowboys and Colorado Buffaloes meet Saturday in college football action at Folsom Field. Here’s a Colorado vs Wyoming Prediction. This article will include a Colorado vs Wyoming Pick.
Wyoming Cowboys Betting Preview
The Wyoming Cowboys beat Northern Iowa, lost to Utah and plays UNLV next. Wyoming has split its last 8 games. Kaden Anderson is completing 58.5 percent of his passes for 535 yards, 3 touchdowns, and 2 interceptions. Chris Durr Jr. and John Michael Gyllenborg have combined for 324 receiving yards and 3 touchdowns, while Jackson Holman has 5 receptions.
The Wyoming Cowboys ground game is averaging 158.7 yards per contest, and Sam Scott leads the way with 203 yards and 1 touchdown. Defensively, Wyoming is allowing 12.7 points and 313 yards per game. Andrew Johnson leads the Wyoming Cowboys with 20 tackles, Ben Florentine has 3 sacks and Brayden Johnson has 1 interception.
Colorado Buffaloes Betting Preview
The Colorado Buffaloes lost to Houston, beat Delaware, and they play BYU next. Colorado has won 9 of its last 14 games. Ryan Staub is completing 57.8 percent of his passes for 362 yards, 3 touchdowns, and 2 interceptions. Sincere Brown and Joseph Williams have combined for 252 receiving yards and 2 touchdowns, while Dekalon Taylor has 10 receptions.
The Colorado Buffaloes ground game is averaging 124 yards per contest, and Simeon Price leads the way with 135 yards and 1 touchdown. Defensively, Colorado is allowing 23.3 points and 430 yards per game. Tawfiq Byard leads the Colorado Buffaloes with 19 tackles, Martavius French II has 1 sack and RJ Johnson has 1 interception.
Wyoming Cowboys @ Colorado Buffaloes Betting Trends: Week 4
Why the Colorado Buffaloes will win
- The favorite has won each of Colorado’s last 10 games at Folsom Field.
- Wyoming has lost each of its last 10 September games as a road underdog.
- Wyoming has failed to cover the spread in five of its last six games in Colorado.
- Colorado has covered the spread in five of its last six games as a favorite in Colorado.
- Wyoming has lost the first half in seven of its last eight road games against non-conference opponents.
- Colorado has won the first quarter in each of its last three home games against non-conference opponents.
Why the Wyoming Cowboys will win
- Wyoming has won four of its last six September games as an underdog against non-AP-ranked teams.
- Colorado has lost three of its last four games.
- Colorado has failed to cover the spread in seven of its last eight games against non-conference opponents at Folsom Field.
- Wyoming has covered the spread in six of its last seven games against non-AP-ranked teams.
- Colorado has lost the first half in three of its last four home games against non-conference opponents.
Total Points Facts
- Each of Wyoming’s last six games have gone UNDER the total points line.
- Each of Colorado’s last four games as a favorite have gone UNDER the total points line.
Colorado Buffaloes Player Prop Facts
- Heading into Week 4, Dekalon Taylor leads Colorado for touchdowns (2) this season.
Wyoming Cowboys Player Prop Facts
- Ben Florentine has recorded at least one sack in four consecutive games – equal-longest streak in the FBS, heading into Week 4.
Matchup/League Facts
- Colorado ranks T1st among FBS teams for red zone percentage this season (100.0).
- Colorado ranks 124th among FBS teams for rushing yards allowed per game this season (204.3).
- Wyoming ranks T10th among FBS teams for H1 opponent points per game this season (3.3).
- Wyoming ranks T10th among FBS teams for red zone percentage against this season (62.5).
Colorado vs Wyoming Prediction
Colorado is the more talented team and has been competitive in its two losses, but it still has questions at quarterback and still isn’t great defensively. Colorado is 116th in total defense and 124th in rushing defense. It also doesn’t seem like if the Buffaloes know if they want to roll with Salter or Staub. Colorado is also 3-10-1 ATS in its last 14 games as a double-digit favorite. Wyoming has lots of questions, especially on offense, but that doesn’t mean we just make Colorado a huge favorite. I’ll grab the points with the Cowboys on the road.
