Stanford Cardinal (1-1) vs. Duke Blue Devils (2-0)
September 19, 2026 4:00 pm EDT
The Line: Duke Blue Devils -410 / Stanford Cardinal 320; Over/Under: 50.5
(Get latest betting odds)
In this article we will formulate a Duke vs Stanford prediction for this College Football game on Saturday, September 19th at Wallace Wade Stadium in Durham, North Carolina. Let’s take a look at the prediction for this Week 3 matchup.
Duke Blue Devils Betting Preview
The Duke Blue Devils are 2-0 this season after they defeated Illinois by a score of 31-27 in their last game. Duke trailed 24-21 at halftime, but they took the lead early in the third and never gave it up in the win. The Blue Devils were out gained by a total of 382-376, went 2-9 on third downs, and won the turnover battle by a total of 1-0 in the game. Walker Eget threw for 206 yards and three touchdowns, while Jonah Burton caught four passes for 76 yards and one score. Nate Sheppard rushed 24 times for 147 yards and one score in the win.
Prior to that game, Duke defeated Tulane by a score of 17-3 in week one. The Blue Devils have scored 24.0 points per game with 168.5 passing yards and 210.0 rushing yards per game, while they have allowed 15.0 points against per game this season. Walker Eget has thrown for 337 yards, three touchdowns, and zero interceptions, while Nate Sheppard has 59 carries for 374 yards and three scores this season.
Stanford Cardinal Betting Preview
The Stanford Cardinal are 1-1 (0-1) this year after they lost to Miami by a score of 45-6 in their last game. Stanford trailed 28-6 at halftime and they were shutout in the second half for the ugly loss. The Cardinal were out gained by a total of 549-299, went 5-15 in third downs, and won the turnover battle by a total of 2-0 in the game. Davis Warren threw for 214 yards, while Caden High caught six passes for 92 yards. Sedrick Irvin rushed six times for 41 yards in the game.
Prior to that loss, Stanford defeated Hawaii by a score of 37-27 in week zero. The Cardinal have scored 21.5 points per game with 265.5 passing yards and 118.0 rushing yards per game, while they have allowed 36.0 points against per game this season. Davis Warren has thrown for 524 yards, one touchdown, and zero interceptions, while Micah Ford has 36 carries for 126 yards and three touchdowns this year.
Why the Duke Blue Devils will win
- Duke has won each of its last 16 games against non-AP-ranked teams at Brooks Field at Wallace Wade Stadium.
- Stanford has lost each of its last 11 road games.
- Duke has covered the spread in each of its last four games in September.
- Stanford has failed to cover the spread in six of its last seven road games.
- Duke has won the first half in each of its last 10 September games as a favorite.
- Duke has won the first quarter in five of its last six games against non-AP-ranked teams at Brooks Field at Wallace Wade Stadium.
Why the Stanford Cardinal will win
- Stanford has covered the spread in four of its last five games.
- The road team has won the first quarter in three of Stanford’s last four games.
Total Points Facts
- Seven of Duke’s last eight games against non-AP-ranked teams have gone OVER the total points line.
- Each of Stanford’s last four games in September have gone OVER the total points line.
Duke Blue Devils Player Prop Facts
- Nate Sheppard has recorded 100+ rushing yards in three consecutive games – equal-longest streak in the FBS, heading into Week 3.
Stanford Cardinal Player Prop Facts
- Heading into Week 3, Chris Davis Jr. ranks 3rd amongst FBS players for kick return yards (158) this season.
Matchup/League Facts
- Duke ranks T8th among FBS teams for H2 opponent points per game this season (3.0).
- Duke ranks T21st among FBS teams for Q4 opponent points per game this season (1.5).
- Stanford ranks 137th among FBS teams for passing yards allowed per game this season (353.5).
- Stanford ranks T128th among FBS teams for points allowed per game this season (36.0).
Duke vs Stanford Prediction
Duke comes into this matchup after a big win over Illinois last week and they are looking to go 3-0 to start the season. Stanford was blown out by Miami in their last game, but they are coming off of a bye week. The Cardinal have allowed 72 points through two games, while they really struggled to move the ball against Miami. I think Duke has a huge QB advantage in this game and their defense is also the better unit, so I like the Blue Devils to get the cover here.
