Eastern Michigan vs Louisiana Prediction Football Picks Today 9/20/25

In this article we will formulate an Eastern Michigan vs Louisiana prediction for this College Football game on Saturday, September 20th at Rynearson Stadium in Ypsilanti, Michigan. Let’s take a look at the prediction for this week 4 matchup. 

Eastern Michigan Eagles Betting Preview

The Eastern Michigan Eagles are 0-3 this year after they lost to Kentucky by a score of 48-23 in their last game. Eastern Michigan trailed 14-3 after the first quarter and 28-16 at halftime, before allowing the first 20 points in the second half for the tough loss. The Eagles were out gained by a total of 492-461, went 4-14 on third downs, and lost the turnover battle by a margin of 1-0 in the game. Noah Kim went 25-42 for 330 yards, one touchdown, and one interception, while Dontae McMillan rushed 13 times for 83 yards. Terry Lockett Jr caught three passes for 90 yards and one score in the loss. The EMU defense recorded zero sacks and just three tackles for loss in the game. 

Eastern Michigan opened the season with a 52-27 loss against Texas State in week one and a 28-23 loss to LIU in week two. The Eagles are averaging 24.3 points per game with 255.7 passing yards and 132.0 rushing yards per game, while they are allowing 42.7 points against per game this season. Noah Kim has completed 62.9% of his passes for 767 yards, four touchdowns, and one interception, while Terry Lockett Jr has caught 16 passes for 230 yards and one score. Dontae McMillan has led the rushing attack with 219 yards and one touchdown on 30 carries this year. 

Louisiana Ragin’ Cajuns Betting Preview

The Louisiana Ragin’ Cajuns are 1-2 this season after they lost to Missouri by a score of 52-10 last week. Louisiana trailed 14-0 after the first quarter and 34-10 at halftime, before getting shutout in the second half in the blowout loss. The Ragin’ Cajuns were out gained by a total of 606-121, went 1-11 on third downs, and won the turnover battle by a margin of 1-0 in the game. Daniel Beale went 1-8 for five yards, while Lunch Winfield went 1-6 for -1 yard. Zylan Perry rushed five times for 86 yards and one score, while Caden Jensen caught one pass for five yards in the game. The Louisiana defense recorded two sacks and four tackles for loss in the defeat. 

Louisiana started the season with a 14-12 loss to Rice in week one, but they did beat McNeese by a score of 34-10 in week two. The Ragin’ Cajuns are averaging 18.7 points per game with 59.3 passing yards and 194.3 rushing yards per game, while they are allowing 25.3 points against per game this season. Daniel Beale has completed 41.7% of his passes for 91 yards and one touchdown, while Shelton Sampson Jr has caught five passes for 63 yards. Zylan Perry is the leading rusher with 30 carries for 226 yards and one score this season. 

Why Eastern Michigan will beat Louisiana

• Eastern Michigan has won nine of its last 10 games against non-conference opponents at Rynearson Stadium.
• Louisiana has lost three of its last four September games as a road favorite.
• Eastern Michigan has covered the spread in each of its last four September games as an underdog.
• Louisiana has failed to cover the spread in five of its last six September games as a road favorite.
• Eastern Michigan has won the first quarter in four of its last five games against non-conference opponents at Rynearson Stadium.
• Eastern Michigan has won the first half in eight of its last 10 games against non-conference opponents at Rynearson Stadium.

Total Points Facts

• Each of Eastern Michigan’s last four games against opponents from the Sun Belt Conference have gone OVER the total points line.
• Each of Louisiana’s last four games against non-AP-ranked teams have gone UNDER the total points line.

Matchup/League Facts

• Eastern Michigan ranks 136th among FBS teams for rushing yards allowed per game this season (291.7).
• Eastern Michigan ranks T1st among FBS teams for red zone percentage this season (100.0).
• Louisiana ranks 136th among FBS teams for passing yards per game this season (59.3).
• Louisiana ranks T132nd among FBS teams for rushing yards allowed per game this season (226.7).

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Eastern Michigan vs Louisiana Prediction 

Both of these teams come into this matchup looking for their first FBS win of the season, but Louisiana does at least have one win this year. The Ragin’ Cajuns hardly moved the ball last week against Missouri, while Eastern Michigan did a decent job of scoring 23 points against Kentucky. The Eagles have been solid offensively, but their defense looks like one of the worst units in the nation. If there was ever a time to step up for the EMU defense, it would be against this Louisiana offense that has plenty of trouble passing the football. We have two bad teams here, so I will side with the team that can score and is at home. Take Eastern to win.