Colorado Buffaloes (1-1) vs. Houston Cougars (2-0)
September 12, 2025 7:30 pm EDT
The Line: Houston Cougars -4.5 / Colorado Buffaloes 4.5; Over/Under: 43.5
(Get latest betting odds)
The Colorado Buffaloes and Houston Cougars meet Friday in college football action at TDECU Stadium. Here’s a Houston vs Colorado Prediction. This article will include a Houston vs Colorado Pick.
Colorado Buffaloes Betting Preview
The Colorado Buffaloes lost to Georgia Tech, beat Delaware, and they play Wyoming and BYU next. Colorado has won 9 of its last 13 games. Kaidon Salter is completing 68.2 percent of his passes for 261 yards, 1 touchdown, and 0 interceptions. Sincere Brown and Dekalon Taylor have combined for 207 receiving yards and 3 touchdowns, while Joseph Williams has 5 receptions.
The Colorado Buffaloes ground game is averaging 138.5 yards per contest, and Simeon Price leads the way with 85 yards on 14 carries. Defensively, Colorado is allowing 17 points and 429.5 yards per game. Reginald Hughes leads the Colorado Buffaloes with 14 tackles, Martavius French II has 1 sack and RJ Johnson has 1 interception.
Houston Cougars Betting Preview
The Houston Cougars beat Stephen F. Austin and Rice, and they play Oregon State and Texas Tech next. The Houston Cougars have split their last 10 games. Conner Weigman is completing 65.2 percent of his passes for 347 yards, 4 touchdowns, and 0 interceptions. Tanner Koziol and Stephon Johnson have combined for 189 receiving yards and 2 touchdowns, while Amare Thomas has 5 receptions.
The Houston Cougars ground game is averaging 197.5 yards per contest, and Dean Connors leads the way with 182 yards and 2 touchdowns. Defensively, Houston is allowing 4.5 points and 186 yards per game. Jalen Garner leads the Houston Cougars with 13 tackles, Brandon Mack II has 1.5 sacks and C.J. Douglas has 1 interception.
Colorado Buffaloes @ Houston Cougars Betting Trends: Week 3
Houston Cougars Player Prop Facts
- Heading into Week 3, Dean Connors ranks T1st amongst qualified players for catch rate (100.0%) this season.
Colorado Buffaloes Player Prop Facts
- Heading into Week 3, Isaiah Hardge ranks T1st amongst qualified players for catch rate (100.0%) this season.
Matchup/League Facts
- Houston ranks T1st among FBS teams for Q1 opponent points per game this season (0.0).
- Houston ranks T1st among FBS teams for Q3 opponent points per game this season (0.0).
- Colorado ranks T1st among FBS teams for Q1 opponent points per game this season (0.0).
- Colorado ranks T1st among FBS teams for 4th down conversion percentage this season (100.0).
Houston vs Colorado Prediction
Houston is going to get the benefit of the doubt because it’s the more talented team and is at home. However, Colorado is 9-4 ATS in its last 13 games as an underdog. Three of those covers were outright victories. Colorado had its chances to beat Georgia Tech, and the defense has been better in coverage and tackling overall.
Houston hasn’t had the toughest schedule up to this point, and is 4-10 ATS in its last 14 games as a home favorite. It feels like oddsmakers and bettors are completely down on Colorado, but Deion has thrived in the underdog role. I’ll grab the points with the Buffs.
