Kansas Jayhawks (5-5) vs. Iowa State Cyclones (6-4)
November 22, 2025 12:00 pm EDT
The Line: Iowa State Cyclones -3.5 / Kansas Jayhawks +3.5; Over/Under: 55.5
(Get latest betting odds)
The Kansas Jayhawks and the Iowa State Cyclones meet in week 13 college football action from Jack Trice Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Iowa State vs Kansas Prediction.
Kansas Jayhawks Recap
The Kansas Jayhawks come into this game looking to bounce back from a 24-20 loss at the hands of the Arizona Wildcats last time out to sit at 5-5 this season. After this game, Kansas will head home to close out the regular season against Utah.
Jayhawks Drop 3 Of Last 4
Jalon Daniels has thrown for 2,190 yards, 21 touchdowns and 3 interceptions on 65.1% passing while also rushing for 345 yards and 3 scores. Daniel Hishaw Jr. leads Kansas in rushing with 430 yards and 4 TDs while Leshon Williams has 414 rushing yards and 6 TDs as well this season. Emmanuel Henderson Jr. has a team-high 41 catches for 638 yards and 5 touchdowns while Boden Groen has 374 receiving yards and 4 TDs and Cam Pickett has 423 receiving yards and 3 TDs. Three more Jayhawks have 100+ receiving yards as well this season. On defense, Trey Lathan has a team-high 69 total tackles including 1.5 sacks while Leroy Harris III has a team-high 4.5 sacks. As a unit, Kansas’ defense has combined for 24 sacks and 4 interceptions so far this season.
Why the Kansas Jayhawks will win
- The underdog has won each of Iowa State’s last four games.
- Iowa State has lost each of its last three games as a favorite.
- Kansas has covered the spread in each of its last six November games as an underdog.
- Iowa State has failed to cover the spread in five of its last six games as a favorite.
Iowa State Cyclones Recap
The Iowa State Cyclones come into this game looking to build on their 20-17 win over TCU last time out to sit at 6-4 this season. After this game, Iowa State will head on the road to close out the regular season against Oklahoma State.
Cyclones Snap Four-Game Slide
Rocco Becht has thrown for 2,230 yards, 12 touchdowns and 9 interceptions on 59.9% passing while Carson Hansen leads the Cyclones in rushing with 721 yards and 5 touchdwons and Abu Sama III has 588 yards and 4 TDs as well on the year. Brett Eskildsen leads Iowa State in receiving with 434 receiving yards in addition to 3 TDs while Benjamin Brahmer has 33 grabs for 388 yards and 5 touchdowns and Chase Sowell has 26 catches for 386 yards and a TD. Gabe Burkle has 26 catches for 302 yards and a touchdown as well on the year. On defense, Marcus Neal Jr. has a team-high 70 total tackles while Iowa State’s defense as a unit has combined for 10 sacks and 9 interceptions so far this season.
Why the Iowa State Cyclones will win
- Kansas has lost six of its last seven road games against non-AP-ranked teams.
- Iowa State has won 11 of its last 13 games against non-AP-ranked teams at Jack Trice Stadium.
- Iowa State has covered the spread in four of its last five home games against teams from Kansas.
- Kansas has failed to cover the spread in three of its last four games.
Total Points Facts
- Each of Iowa State’s last eight home games in November have gone UNDER the total points line.
- Five of Kansas’ last six November games as an underdog have gone UNDER the total points line.
Iowa State vs Kansas Prediction
I’m on Kansas and the points here. I get why Iowa State’s favored at home on Senior day, but the Cyclones already have a bowl game locked up. While no team will say they’re going to lose against another team, I think Kansas would view this as a much more winnable spot than to try to knock off a Utah team. They’re aiming for style points for a college football playoff spot next week. Even at home. The Cyclones haven’t been all that impressive this season, and I still believe that Kansas is the better team here. Give me the Jayhawks and the points in a game I think Kansas can win outright.
