Iowa State vs Oklahoma State Prediction Football Picks Today 11/29/25
Iowa State Cyclones (7-4) vs. Oklahoma State Cowboys (1-10)
November 29, 2025 12:00 pm EDT
The Line: Oklahoma State Cowboys 425 / Iowa State Cyclones -575; Over/Under: 46.5
(Get latest betting odds)
In this article, we will formulate an Iowa State vs Oklahoma State Prediction for this College Football Week 14 game on Saturday, November 29th. Let’s take a look at the prediction for this College Football matchup.
Oklahoma State Cowboys Preview
Oklahoma State has a 1-10 record this season and is sitting 16th in the Big 12. They are coming off a 17-14 road loss against UCF. Offensively, Oklahoma State averages 14.3 points per game, ranking 134th in the nation, while defensively, they allow 34.5 points per game, which is 127th. Oklahoma State averages 298.2 total yards per game (171.5 passing and 126.6 rushing), while allowing 424.9 total yards per game (159.8 rushing and 265.1 passing).
Zane Flores leads Oklahoma State with 1,288 passing yards with 58.6% completed passes and 3 touchdowns. Rodney Fields Jr. leads the team in rushing yards with 614, while Gavin Freeman has a team-high 46 receptions for 435 receiving yards. Defensively, Parker Robertson has a team-high 70 total tackles (42 of them solo), while Wendell Gregory leads the team in sacks, with 4.0, and Parker Robertson and LaDainian Fields lead the team with 2 interceptions each.
Iowa State Cyclones Preview
Iowa State has a 7-4 record this season and is sitting 8th in the Big 12. They are coming off a 38-14 home win against Kansas. Offensively, Iowa State averages 28.1 points per game, ranking 66th in the nation, while defensively, they allow 20.8 points per game, which is 33rd. Iowa State averages 400.6 total yards per game (231.3 passing and 169.4 rushing), while allowing 368.1 total yards per game (148.1 rushing and 220 passing).
Rocco Becht leads Iowa State with 2,471 passing yards with 61.3% completed passes and 15 touchdowns. Abu Sama leads the team in rushing yards with 645, while Chase Sowell has a team-high 28 receptions for 446 receiving yards. Defensively, Marcus Neal has a team-high 75 total tackles (33 of them solo), while Caleb Bacon leads the team in sacks, with 0.5, and Jamison Patton and Jontez Williams lead the team with 2 interceptions each.
Iowa State Cyclones @ Oklahoma State Cowboys Betting Trends: Week 14
Why the Oklahoma State Cowboys will win
- The underdog has won four of Iowa State’s last five games.
- Iowa State has lost each of its last five games in Oklahoma.
- Iowa State has failed to cover the spread in seven of its last eight games against teams from Oklahoma.
- Oklahoma State has covered the spread in four of its last five games against Iowa State.
- Oklahoma State has won the first quarter in each of its last three games against conference opponents.
Why the Iowa State Cyclones will win
- Oklahoma State has lost each of its last 18 games against conference opponents.
- The favorite has won each of Oklahoma State’s last eight games.
- Oklahoma State has failed to cover the spread in nine of its last 11 home games.
- The road team has covered the spread in three of Iowa State’s last four games.
- Iowa State has won the first quarter in three of its last four games against conference opponents.
- Oklahoma State has lost the first half in each of its last nine home games against conference opponents.
Total Points Facts
- Each of Iowa State’s last four games against non-AP-ranked teams have gone UNDER the total points line.
- Five of Oklahoma State’s last six games as a home underdog have gone OVER the total points line.
Oklahoma State Cowboys Player Prop Facts
- Heading into Week 14, Wes Pahl ranks 1st in the Big 12 Conference amongst qualified players for gross average yards per punt (46.5) this season.
Iowa State Cyclones Player Prop Facts
- Heading into Week 14, Carson Hansen is one of only 19 players in the FBS to record 100+ rushing yards in three or more consecutive games this season.
Matchup/League Facts
- Oklahoma State ranks 135th among FBS teams for H2 points per game this season (5.5).
- Oklahoma State ranks 135th among FBS teams for average point differential in third quarters this season (-6.8).
- Iowa State ranks T21st among FBS teams for 4th down conversion percentage against this season (41.7).
- Iowa State ranks T22nd among FBS teams for 4th down conversion percentage this season (65.4).
Iowa State vs Oklahoma State Prediction
In this Iowa State vs Oklahoma State Prediction, Iowa State is coming as -14-point road favorites. Oklahoma State has been atrocious this season, with just one win in their 11 games played, a 1-5 home record and a terrible 3-7 against the spread record. On the flip side, Iowa State has back-to-back wins following a four-game losing skid and are superior both offensively and defensively, as Oklahoma State is a bottom-10 squad in the country in both categories. Take Iowa State and lay the big number on the road in this one.