Iowa vs Iowa State
September 6, 2025 12:00 pm EDT
The Line: Iowa State -3 / Over/Under: 41.5
(Get latest betting odds)
In this article, we will formulate an Iowa vs Iowa State Prediction for this College Football Week 2 game on Saturday, September 6th at the Jack Trice Stadium. Let’s take a look at the prediction for this College Football matchup.
Iowa State Cyclones Preview
The Cyclones are coming off a 55-7 home victory over South Dakota in their previous game, and are a perfect 2-0 this season. Iowa State outgained their opponents by 529-208 yards. They had 23/25 completed passes, 306 passing yards, 223 rushing yards, with turnovers being 0-2. The Cyclones went 9-10 in third down efficiency and had 3-30 penalties.
Rocco Becht had 19/20 passes, a team-high 278 passing yards and three touchdowns. Abu Sama III added a team-high 68 rushing yards, while Jayden Higgins caught 6 passes for 123 yards and one touchdown. Defensively, Caleb Bacon had nine total tackles, three of them solo, while Tyler Onyedim had one sack. Myles Purchase had one interception for 17 yards.
Iowa Hawkeyes Preview
The Hawkeyes are coming off a 34-7 home victory over Albany in their season opener. Iowa outgained their opponents by 358-177 yards. They had 9/16 completed passes, 48 passing yards, 310 rushing yards, with turnovers being 1-0. The Hawkeyes went 10-16 in third down efficiency and had 2-20 penalties.
Mark Gronowski had 8/15 passes, a team-high 44 passing yards and one touchdown. Kamari Moulton added a team-high 122 rushing yards and one touchdown, while Jacob Gill caught 1 pass for 13 yards. Defensively, Jayden Harrell had six total tackles, five of them solo, while Max Llewellyn had one sack. Sebastian Castro had one interception for 25 yards.
Why the Iowa State Cyclones will win
- Iowa has lost each of its last eight games against AP-ranked teams.
- Iowa State has won nine of its last 10 games against non-AP-ranked teams at Jack Trice Stadium.
- Iowa has failed to cover the spread in each of its last nine games against AP-ranked teams.
- Iowa State has covered the spread in each of its last four games against non-conference opponents.
- Iowa State has won the first quarter in seven of its last eight games against non-conference opponents at Jack Trice Stadium.
- Iowa State has won the first half in 13 of its last 15 games against non-conference opponents at Jack Trice Stadium.
Why the Iowa Hawkeyes will win
- Iowa State has lost each of its last six home games against opponents from the Big Ten Conference.
- Iowa has won 14 of its last 16 games in Iowa.
- The road team has covered the spread in each of the last four games between Iowa and Iowa State.
- Iowa State has failed to cover the spread in four of its last five games as a favorite against teams from Iowa.
- Iowa has won the first quarter in four of its last five games against non-conference opponents.
- Iowa State has lost the first half in each of its last four games against opponents from the Big Ten Conference.
Total Points Facts
- Each of Iowa’s last six games as an underdog in Iowa have gone UNDER the total points line.
- Each of Iowa State’s last five home games against teams from Iowa have gone UNDER the total points line.
Matchup/League Facts
- Iowa State ranks T1st among FBS teams for Q3 opponent points per game this season (0.0).
- One of Iowa State’s two games this season have been decided by a margin of seven points or less – equal-most amongst FBS teams.
- Iowa ranks T1st among FBS teams for Q1 opponent points per game this season (0.0).
- Iowa ranks T1st among FBS teams for Q3 opponent points per game this season (0.0).
Iowa vs Iowa State Prediction
In their previous meeting last season, Iowa State won 20-19 on the road, not covering the spread, as the game went over the point total. Iowa is 7-2 in their last 9 head-to-head meetings, but both teams are 4-4 against the spread in their last 8 meetings. Under is 7-2-1 in their last 10 meetings.
In this Iowa vs Iowa State Prediction, Iowa State is coming in as -3.5-point home favorites, with the total set at 41.5 points. Both teams are coming off dominating victories in their previous games, as they won by 48 and 27 points respectively. The Cyclones were almost perfect at home last season with a 6-1 record, and even though they are dominated by the Hawkeyes at their home court, this it the team were this trend ends. The Cyclones looked far better in their win over South Dakota and have an extra game under their belt. Take the Iowa State Cyclones and lay the points at home.
