Iowa vs Michigan State Prediction Football Picks Today 11/22/25

The Michigan State Spartans and the Iowa Hawkeyes meet in week 13 college football action from Kinnick Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Iowa vs Michigan State Prediction.

Michigan State Spartans Recap

The Michigan State Spartans come into this game looking to bounce back from a 28-10 loss at the hands of Penn State last time out to sit at 3-7 this season. After this game, Michigan State will head home for a game against Maryland to close out the regular season.

Spartans Drop 7 In A Row

Aidan Chiles has thrown for 1,392 yards, 10 touchdowns and 3 interceptions on 63.1% passing while Alessio Milivojevic has thrown for 720 yards, 4 touchdowns and an interception on 64.1% passing. Makhi Frazier has a team-high 520 rushing yards and 2 TDs while Elijah Tau-Tolliver has 298 rushing yards and 2 TDs. Nick Marsh has a team-high 48 catches for 559 yards and 5 TDs to lead MSU in receiving while Omari Kelly has 41 grabs for 544 yards and a TD. Jordan Hall leads the Spartans’s defense with 74 total tackles while Michigan State’s defense as a whole has combined for 17 sacks and 3 interceptions so far this season. 

Why the Michigan State Spartans will win

• The road team has covered the spread in 11 of Michigan State’s last 12 games.
• Iowa has failed to cover the spread in 12 of its last 16 November games as a home favorite against non-AP-ranked teams.

Iowa Hawkeyes Recap

The Iowa Hawkeyes come into this game looking to bounce back from a 26-21 loss at the hands of USC last time out to sit at 6-4 this season. After this game, Iowa will head on the road to close out the regular season against Nebraska.

Hawkeyes Drop Back-To-Back Games

Mark Gronowski has thrown for 1,216 yards, 6 touchdowns and 5 interceptions on 63.9% passing while also rushing for 370 yards and 13 touchdowns this season. Kamari Moulton leads Iowa with 612 rushing yards along with 2 touchdowns while Xavier Williams has 258 rushing yards and 3 TDs and Jaziun Patterson has 263 rushing yards. Jacob Gill leads the Hawkeyes in receiving with 18 grabs for 237 yards while Sam Phillips has 216 receiving yards this season. On defense, Karson Sharar leads Iowa with 63 total tackles while Max Llewellyn has a team-high 6 sacks and Ethan Hurkett and Aaron Graves each have 5 sacks. As a unit, Iowa’s defense has combined for 19 sacks and 10 interceptions this season. 

Why the Iowa Hawkeyes will win

• Iowa has won each of its last nine home games against non-AP-ranked teams.
• Michigan State has lost each of its last eight road games.
• Iowa has covered the spread in seven of its last eight games.
• Michigan State has failed to cover the spread in six of its last seven games in November.

Total Points Facts

• Each of Iowa’s last four games as a favorite against teams from Michigan have gone OVER the total points line.
• Six of Michigan State’s last seven road games in November have gone UNDER the total points line.

Iowa vs Michigan State Prediction

I’m on the under in this one. I just think this is going to be a game where the ball stays on the ground a ton and the clock continues to keep moving throughout. Furthermore, I wouldn’t be surprised if we managed to stay under 30 points when all is said and done here, whether it’s 23-6 or 17-13. Either way, give me the under here.