College Football

James Madison vs Old Dominion Prediction Football Picks Today 9/26/26

James Madison Dukes (3-0) vs. Old Dominion Monarchs (1-2)
September 26, 2026 6:00 pm EDT
The Line: Old Dominion Monarchs 185 / James Madison Dukes -225; Over/Under: 44.5
(Get latest betting odds)

In this article, we will formulate a James Madison vs Old Dominion Prediction for this College Football Week 4 matchup on Saturday, September 26th. Let’s take a look at the prediction for this College Football matchup.

Old Dominion Monarchs Preview

Old Dominion has a 1-2 record and are coming off a 17-20 home loss against East Carolina. They will face Georgia State and App State next. Offensively, Old Dominion averages 23 points per game, ranking 110th in the nation, while defensively, they allow 24.7 points per game, which is 88th. Old Dominion averages 301 total yards per game (141.3 passing and 159.7 rushing), while allowing 304 total yards per game (129.3 rushing and 174.7 passing).

Quinn Henicle leads Old Dominion with 424 passing yards with 56.6% completed passes and 3 touchdowns, also adding a team-high 224 rushing yards. Josh Rodriguez has a team-high 8 receptions for 121 receiving yards. Defensively, Mario Thompson has a team-high 28 total tackles (5 of them solo), while Jackson Forrest leads the team with 3 sacks.

James Madison Dukes Preview

James Madison has a 3-0 record and are coming off a 26-13 road win against San Diego State. They will face Marshall and Georgia Southern next. Offensively, James Madison averages 44.3 points per game, ranking 17th in the nation, while defensively, they allow 9.7 points per game, which is 9th. James Madison averages 432 total yards per game (220.3 passing and 211.7 rushing), while allowing 308.7 total yards per game (123 rushing and 185.7 passing).

Camden Coleman leads James Madison with 473 passing yards with 66% completed passes and 5 touchdowns. George Pettaway leads the team in rushing yards with 181, while Corey Scott has a team-high 12 receptions for 128 receiving yards. Defensively, Nakian Jackson has a team-high 25 total tackles (11 of them solo), while Ken Willis leads the team with one sack.

James Madison Dukes @ Old Dominion Monarchs Betting Trends: Week 4

 

Why the Old Dominion Monarchs will win

  • Old Dominion has won seven of its last eight home games.
  • Old Dominion has covered the spread in five of its last six September games as a home underdog.
  • Old Dominion has won the first quarter in six of its last eight games as an underdog against non-AP-ranked teams.
  • Old Dominion has won the first half in seven of its last eight home games.

Why the James Madison Dukes will win

  • James Madison has won each of its last 14 games against non-AP-ranked teams.
  • Old Dominion has lost 10 of its last 11 games as an underdog against teams from Virginia.
  • James Madison has covered the spread in each of its last eight games in September.
  • Old Dominion has failed to cover the spread in each of its last six home games against teams from Virginia.
  • James Madison has won the first half in each of its last six games against conference opponents.
  • James Madison has won the first quarter in eight of its last nine games against non-AP-ranked teams.

Total Points Facts

  • Eight of Old Dominion’s last nine games have gone UNDER the total points line.
  • Five of James Madison’s last six games against conference opponents have gone OVER the total points line.

Old Dominion Monarchs Player Prop Facts

  • Heading into Week 4, Jackson Forrest ranks T9th amongst FBS players for sacks (3.0) this season.

James Madison Dukes Player Prop Facts

  • Heading into Week 4, Nick Herman ranks 10th amongst qualified players for Yards Per Carry (8.5) this season.

Matchup/League Facts

  • Old Dominion ranks T1st among FBS teams for red zone percentage this season (100.0).
  • Old Dominion ranks T133rd among FBS teams for 1st downs this season (41).
  • James Madison ranks 137th among FBS teams for time of possession per game this season (25:11).
  • James Madison ranks T3rd among FBS teams for H1 opponent points per game this season (3.0).

James Madison vs Old Dominion Prediction

In this James Madison vs Old Dominion Prediction, James Madison is coming as -5.5 road favorites. James Madison has been undefeated this season and has been the far better team so far, ranking on the top-20 of the country both offensively and defensively, for a +34.6 point differential. They have covered the spread in all three games, while Old Dominion is 0-3 ATS this season and have never won against James Madison, having lost all of their four meetings and are 1-3 ATS. Take James Madison to win and cover on the road in this one.

Nikos Lagouretos's Free Pick: James Madison -5.5

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