Kansas vs Cincinnati Prediction Football Picks Today 9/27/25

Kansas and Cincinnati meet Saturday in Week 5 college football action from David Booth Kansas Memorial Stadium. Here’s a Kansas vs Cincinnati prediction. We will look at this from a betting perspective and determine the best Kansas Jayhawks vs Cincinnati Bearcats pick.

Kansas Made a Statement

After the disappointing loss against Missouri in the last game, the Jayhawks made a huge statement in the last game. Kansas scored 41 points, but maybe even more important was the defense that gave up only 10 points on the way to the blowout win. Jalon Daniels had another solid game, finishing with 138 yards and three passing touchdowns. Leshon Williams also had a huge game on the ground rushing 19 times for 129 yards and a touchdown. The defense also made life very tough on the West Virginia defense, and they are going to need the defense to be elite again here. 

Kansas on the season is averaging 37.25 points while their defense is giving up 16.5 points per game. The offense is ranked 36th in the league while the defense is ranked 32nd. In this game two things need to happen. Kansas has to jump out to a fast start, and they have to try and create a couple of turnovers. 

Can Cincinnati Make a Statement?

Cincinnati lost the first game of the season against Nebraska but since then they have won two straight games. Two games ago against Bowling Green, the Bearcats won 34-20 and in the last game against Northwestern State they won 70-0. Brendan Sorsby had quite the game completing 15 of his 15 passes for 253 yards, five touchdowns, and zero interceptions. Caleb Goodie also caught three passes for 106 yards and a touchdown. 

The Bearcats on the season are averaging 40.33 points while their defense is giving up 13.33 points per game. The offense is ranked 24th in the league while the defense is 20th in college football. The defense hasn’t given up a point in the 1st quarter this season, and they are going to need that defense to show up again here.

Why the Cincinnati Bearcats will win

• Kansas has lost three of its last four September games as a favorite against non-AP-ranked teams.
• Cincinnati has won eight of its last 10 September road games against non-AP-ranked teams.
• Kansas has failed to cover the spread in five of its last six September games against non-AP-ranked teams.

Why the Kansas Jayhawks will win

• The home team has won each of Kansas’ last six games.
• Cincinnati has lost five of its last six road games against conference opponents.
• Kansas has covered the spread in six of its last seven games against conference opponents.
• Cincinnati has failed to cover the spread in five of its last six games as a road underdog.

Kansas vs Cincinnati Prediction

Kansas is going to have no issue getting the job done in this game. Jalon Daniels is the real deal for Kansas and he’s going to have another big game here. Not only does he beat you through the air, he can do it with the legs, and the Bearcats defense is going to have no issue. Outside of the Missouri game, the defense has also been strong for Kansas, and they are going to make life really tough on Sorsby. Kansas is going to jump out to a fast start, and Cincinnati will have no answer. Back Kansas to win this game and cover the spread.