Kansas vs West Virginia Prediction Football Picks Today 9/20/25

Kansas and West Virginia meet Saturday in Week 4 college football action from David Booth Kansas Memorial Stadium. Here’s a Kansas vs West Virginia prediction. We will look at this from a betting perspective and determine the best West Virginia Mountaineers vs Kansas Jayhawks pick. 

Kansas Has to Bounce Back

Kansas is coming off a bye week, but its last game was a loss against Missouri. They had so many chances to win that game, but they kept making mistakes late in the game that ended up costing them. The Jayhawks’ offense scored 31 points, but the defense gave up 42 points and that led to the defeat. Kansas finished the game with 254 yards, but its defense gave up 595 yards. The offense finished with only 31 rushing yards, and they are going to need a more balanced offensive attack. 

In the first game of the season, Kansas was able to pick up the 31-7 victory, and in the last game against Wagner, the Jayhawks were able to secure the 46-7 victory. Kansas on the season, is averaging 36 points while their defense is giving up 18.86 points per game. The offense is ranked 48th while the defense is ranked 52nd. Jalon Daniels has played well and he has thrown for 679 yards, nine touchdowns, and two interceptions. 

Why Kansas Will Beat West Virginia

• Kansas has won each of its last five home games.
• West Virginia has lost three of its last four games against teams from Kansas.
• Kansas has covered the spread in four of its last five home games.
• West Virginia has failed to cover the spread in each of its last three games at David Booth Kansas Memorial Stadium.

What a Two Weeks for West Virginia

It was quite the last two weeks for West Virginia, one was good, and the other wasn’t. Two games ago against Ohio, West Virginia scored only 10 points, and they ended up losing by seven points. In the last game against Pittsburgh, it took overtime, but West Virginia was able to secure the 31-24 victory. At halftime, they only had scored three points, but the defense had stepped up to keep them in the game. The Mountaineers had 434 total yards, and 260 of them came through the air. Nicco Marchiol was banged up, and he completed 19 of his 25 passes for 192 yards, one touchdown, and zero interceptions. 

WVU on the season is averaging 28.67 points while their defense is giving up 14.67 points per game. The offense is ranked 73rd while the defense is ranked 33rd. In this game, it’s going to need to be the defense that steps up and really makes life tough on Daniels. 

Why West Virginia Will Beat Kansas

• West Virginia has won 10 of its last 12 games as an underdog against non-AP-ranked teams.
• Kansas has lost each of its last five September games against non-AP-ranked teams.
• Kansas has failed to cover the spread in seven of its last eight games in September.
• West Virginia has covered the spread in 10 of its last 12 games as an underdog against non-AP-ranked teams.

Kansas vs West Virginia Prediction

West Virginia is riding high heading into this game, and although I don’t think they win, I do think their offense is going to be good. The big weakness of this Jayhawks team is the defense, and it’s going to hurt them again here. Marchiol was good in his last game, and he’s going to have another dominant game again here. Jalon Daniels is a star for Kansas and he’s been playing quite impressively. The Jayhawks’ offense is going to have no issue putting on a show against the West Virginia defense. There will be zero defense played by either team, and this game is going to end up over the total. This is a very strong play.