Louisiana vs Missouri Prediction 9/13/25 College Football Picks Today

In this article, we will formulate a Louisiana vs Missouri Prediction for this College Football Week 3 game on Saturday, September 13^th at the Memorial Stadium. Let’s take a look at the prediction for this College Football matchup.

Missouri Tigers Preview

The Tigers have a 2-0 record this season and are ranked as No.101 in the College Football Top 136 Team Rankings for 2025. Ohio State is number 1, Penn State is number 2 and LSU is number 3 in the rankings. The Tigers are coming off a 42-31 home victory over Kansas. Missouri outgained their opponents by 595-251 yards. They had 30/39 completed passes, 334 passing yards, 261 rushing yards, with turnovers being 1-1. The Tigers went 10-19 in third down efficiency and had 7-70 penalties.

Beau Pribula had 30/39 passes, a team-high 334 passing yards, three touchdowns and no interceptions. Jamal Roberts added a team-high 143 rushing yards, while Kevin Coleman Jr. caught 10 passes for 126 yards. Defensively, Jalen Catalon had 6 total tackles, three of them solo, while Zion Young recorded 1 sack. Daylan Carnell had one interception.

Louisiana Ragin’ Cajuns Preview

The Ragin’ Cajuns have a 1-1 record this season and are ranked as No.25 in the College Football Top 136 Team Rankings for 2025. Ohio State is number 1, Penn State is number 2 and LSU is number 3 in the rankings. The Ragin’ Cajuns are coming off a 34-10 home victory over McNeesee. Louisiana outgained their opponents by 401-238 yards. They had 14/22 completed passes, 86 passing yards, 315 rushing yards, with turnovers being 0-2. The Ragin’ Cajuns went 4-11 in third down efficiency and had 6-55 penalties.

Daniel Beale had 14/22 passes, a team-high 86 passing yards, one touchdown and no interceptions. Bill Davis added a team-high 132 rushing yards, while KeDarius Wade caught 1 pass for 19 yards. Defensively, Maurion Eleam had 6 total tackles, six of them solo, while Caleb Kibodi recorded 1 sack. Jalen Clark had one interception.

Louisiana Ragin’ Cajuns @ Missouri Tigers Betting Trends: Week 3

Why the Missouri Tigers will win

• Missouri has won each of its last 21 games against non-conference opponents at Faurot Field at Memorial Stadium.
• Louisiana has lost nine of its last 12 road openers.
• Missouri has covered the spread in each of its last eight games against non-AP-ranked teams.
• Louisiana has failed to cover the spread in three of its last four games.
• Missouri has won the first half in 20 of its last 21 games against non-conference opponents at Faurot Field at Memorial Stadium.
• Missouri has won the first quarter in 17 of its last 21 games against non-conference opponents at Faurot Field at Memorial Stadium.

Why the Louisiana Ragin’ Cajuns will win

• Louisiana has won four of its last six September games as a road underdog.
• Louisiana has covered the spread in three of its last four games in September.

Total Points Facts

• Seven of Louisiana’s last eight games against opponents from the Southeastern Conference have gone OVER the total points line.
• Six of Missouri’s last seven games have gone OVER the total points line.

Missouri Tigers Player Prop Facts

• Ahmad Hardy has recorded 100+ rushing yards in four consecutive games – equal-longest streak in the FBS, heading into Week 3.

Louisiana Ragin’ Cajuns Player Prop Facts

• Heading into Week 3, Jalen Clark leads the Sun Belt Conference for interceptions (1) this season.

Matchup/League Facts

• Missouri ranks T1st among FBS teams for Q4 points per game this season (17.5).
• Missouri ranks T1st among FBS teams for Q2 opponent points per game this season (0.0).
• Louisiana ranks T1st among FBS teams for Q4 opponent points per game this season (0.0).
• Louisiana ranks 133rd among FBS teams for passing yards per game this season (87.0).

Louisiana vs Missouri Prediction

This will be the first meeting between those two teams.

In this Louisiana vs Missouri Prediction, Missouri is coming in as -27.5-point home favorites, with the total set at 47.5 points. Both teams are coming off dominating wins in their previous games, as Missouri won Kansas by 11 points and Louisiana won by 24. The Tigers were undefeated at home last season, winning all of their 8 home games, and were 8-4 against the spread, and have the luxury of playing their third straight game at home to start the season. I like the hosts to keep rolling and cover the spread in this one, as they have done in both of their games this season. Take the Missouri Tigers and lay the -27.5 points at home.

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