Louisville vs Boston College Prediction Football Picks Today 10/25/25

The Boston College Eagles and the Louisville Cardinals meet in week 9 college football action from L&N Federal Credit Union Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Boston College Eagles vs. Louisville Cardinals prediction.

Boston College Eagles Recap

The Boston College Eagles come into this game looking to bounce back from a 38-23 loss at the hands of UConn last time out to sit at 1-6 this season. After this game, Boston College will head home for a game against Notre Dame.

Eagles Drop 6th In A Row

Dylan Lonergan has thrown for 1,394 yards, 9 touchdowns and 3 interceptions on 67% passing while Turbo Richard has rushed for a team-high 431 yards and 5 touchdowns so far this season. Lewis Bond leads the Eagles with 50 receptions for 505 yards while Reed Harris has 337 receiving yards and 3 touchdowns and Jeremiah Franklin has 26 catches for 266 yards and a score. Four more Eagles have 100+ receiving yards as well this season. On defense, KP Price has a team-high 55 total tackles including 34 solo tackles while the Eagles’ defense as a whole has combined for 12 sacks and 4 interceptions so far this season.

Why the Boston College Eagles will win

• The road team has won each of Louisville’s last three games.
• Louisville has lost each of its last three home games in October.
• Boston College has covered the spread in each of its last five games against AP-ranked teams.
• Louisville has failed to cover the spread in each of its last four home games.

Louisville Cardinals Recap

The Louisville Cardinals come into this game looking to build on their 24-21 win over Miami last time out to improve to 5-1 on the year. After this game, Louisville will head on the road for a game against Virginia Tech.

Cardinals Looking For Big Win At Home

Miller Moss has thrown for 1,606 yards, 9 touchdowns and 4 interceptions on 66.2% passing while Isaac Brown leads Louisville in rushing with 447 rushing yards and 3 touchdowns and Keyjuan Brown has 132 rushing yards and 3 TDs as well. Chris Bell leads Louisville with 44 grabs for 638 receiving yards and 6 touchdowns while Caullin Lacy has 32 catches for 326 yards this season. Two more Louisville receivers have 100+ receiving yards as well this season. On defense, D’Angelo Hutchinson and TJ Quinn each have a team-high 37 total tackles and an interception while Clev Lubin has a team-high 4 sacks. As a unit, Louisville’s defense has combined for 14 sacks and 10 interceptions so far this season.

Why the Louisville Cardinals will win

• Louisville has won each of its last seven games against non-AP-ranked teams.
• Boston College has lost each of its last six games.
• Boston College has failed to cover the spread in each of its last five games.
• The home team has covered the spread in each of the last five games between Boston College and Louisville.

Total Points Facts

• Eight of the last nine games between Boston College and Louisville have gone OVER the total points line.
• Each of Boston College’s last four October games against AP-ranked teams have gone UNDER the total points line.

Boston College Eagles vs. Louisville Cardinals Prediction

I’m on the Cardinals here. It’s a bit of a letdown spot for Louisville here after a big road win over Miami, but my problem here is that Boston College has shown us nothing up until this point to suggest they’ll be able to keep this game close as BC has been getting crushed left and right all season long. I think Louisville uses this as a game to gain some style points and just beat up on a bad opponent so give me the Cardinals at home laying the big number.