College Football

Louisville vs Pittsburgh Prediction 11-23-24 College Football Picks

Pittsburgh Panthers (7-3) vs. Louisville Cardinals (6-4)
November 23, 2024 4:00 pm EDT
The Line: Louisville Cardinals -8.5 / Pittsburgh Panthers +8.5; Over/Under: +57.5
(Get latest betting odds)

The Pittsburgh Panthers and Louisville Cardinals meet Saturday in week 13 college football action at L&N Federal Credit Union Stadium. Here’s a Louisville vs Pittsburgh Prediction. This article will include a Louisville vs Pittsburgh Pick.

Pittsburgh Panthers Betting Preview

The Pittsburgh Panthers lost to Virginia and Clemson, and they play Boston College next. Pittsburgh has won 2 of its last 3 road games. Eli Holstein is completing 61.9 percent of his passes for 2,174 yards, 17 touchdowns, and 6 interceptions. Konata Mumpfield and Desmond Reid have combined for 1,154 receiving yards and 7 touchdowns, while Kenny Johnson has 37 receptions.


The Pittsburgh Panthers ground game is averaging 144.4 yards per contest, and Reid leads the way with 738 yards and 4 touchdowns. Defensively, Pittsburgh is allowing 25 points and 359.9 yards per game. Donovan McMillon leads the Pittsburgh Panthers with 84 tackles, Kyle Louis has 7 sacks and Brandon George has 1 interception.

Louisville Cardinals Betting Preview

The Louisville Cardinals beat Clemson, lost to Stanford, and they play Kentucky next. Louisville has won 3 of its last 5 home games. Tyler Shough is completing 63.6 percent of his passes for 2,774 yards, 21 touchdowns, and 6 interceptions. Ja’Corey Brooks and Chris Bell have combined for 1,437 receiving yards and 11 touchdowns, while Ahmari Huggins-Bruce has 18 receptions.

The Louisville Cardinals ground game is averaging 163 yards per contest, and Isaac Brown leads the way with 803 yards and 7 touchdowns. Defensively, Louisville is allowing 25.6 points and 372.8 yards per game. Ty Quinn leads the Louisville Cardinals with 66 tackles, Tramel Logan has 4 sacks and T.J. Capers has 1 interception.

Why the Louisville Cardinals will win

  • Pittsburgh has lost each of its last four games in November.
  • The home team has won each of the last four games between Pittsburgh and Louisville.
  • Pittsburgh has failed to cover the spread in each of its last five November games as a road underdog.
  • The favorite has covered the spread in four of Louisville’s last five games at L&N Federal Credit Union Stadium.
  • Louisville has won the first half in six of its last eight home games against conference opponents.

Total Points Facts

  • Each of Pittsburgh’s last four games against non-AP-ranked teams has gone UNDER the total points line.
  • Each of Louisville’s last four November games against non-AP-ranked teams has gone OVER the total points line.

Matchup/League Facts

  • Louisville ranks T9th among FBS teams for Q3 points per game this season (9.9).
  • Louisville ranks T10th among FBS teams for H2 points per game this season (18.2).
  • Pittsburgh ranks 4th among FBS teams for Q4 points per game this season (11.6).
  • Pittsburgh ranks 4th among FBS teams for average point differential in fourth quarters this season (+6.9).

Louisville vs Pittsburgh Prediction

The Louisville Cardinals are getting the benefit of the doubt because they’re at home, but they just lost to Stanford as three-touchdown favorites. You can argue the Pittsburgh Panthers are the better, more balanced team, and they’re 7-3 ATS on the season. Not sure how anybody can see what Louisville did last week and return to lay more than a touchdown. The gap between Louisville and Pitt isn’t that wide. Give me the points.

Randy Chambers's Free Pick: Pittsburgh Panthers +8.5

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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