Memphis vs South Florida Prediction Football Picks Today 10/25/25

In this article we will formulate a Memphis vs South Florida prediction for this College Football game on Saturday, October 25th at Simmons Bank Liberty Stadium in Memphis, Tennessee. Let’s take a look at the prediction for this week 9 matchup. 

Memphis Tigers Betting Preview

The Memphis Tigers are 6-1 (2-1) this year after they lost to UAB by a score of 31-24 in their last game. Memphis trailed 31-17 in the fourth quarter, but they cut the deficit to 31-24, before getting stopped inside the 10 for the loss. The Tigers were out gained by a total of 470-362, went 5-11 on third downs, and won the turnover battle by a total of 2-1 in the game. AJ Hill went 13-25 for 175 yards, one touchdown, and one interception, while Greg Desrosiers Jr rushed 11 times for 74 yards and one score. Cortez Braham Jr led the receivers with five catches for 83 yards in the loss. The Memphis defense recorded one sack and four tackles for loss in the game. 

Prior to that game, Memphis defeated Tulsa by a score of 45-7 and FAU by a score of 55-26. The Tigers have won six of their first seven games and they are currently tied for fourth in the American standings. Memphis has scored 38.1 points per game with 216.0 passing yards and 221.6 rushing yards per game, while they have allowed 18.3 points against per game this season. Brendon Lewis is the starting quarterback for Memphis, but he is questionable with an injury. Cortez Braham Jr has 29 receptions for 491 yards and five scores this year. 

South Florida Bulls Betting Preview

The South Florida Bulls are 6-1 (3-0) this season after they defeated FAU by a score of 48-13 in their last game. South Florida led 21-6 at halftime, but their lead was cut to 21-13, before scoring the last 27 points in the blowout win. The Bulls out gained FAU by a total of 522-312, went 9-18 on third downs, and won the turnover battle by a margin of 1-0 in the game. Byrum Brown went 14-24 for 256 yards and three touchdowns, while also rushing for 111 yards and one score on 14 carries. Jeremiah Koger led the receivers with four catches for 90 yards and one touchdown in the win. The USF defense recorded five sacks and 11 tackles for loss in the game. 

Prior to that game, South Florida defeated North Texas by a score of 63-36 and Charlotte by a score of 54-26. The Bulls have won four games in a row and they are currently tied for second in the American standings. South Florida has scored 41.7 points per game with 260.4 passing yards and 215.6 rushing yards per game, while they have allowed 23.0 points against per game this season. Byrum Brown has thrown for 1,695 yards, 16 touchdowns, and five interceptions, while also rushing for 475 yards and six scores on 99 carries this season. 

Why the South Florida Bulls will win

• South Florida has won seven of its last eight games.
• Memphis has lost each of its last six October games as an underdog.
• The road team has covered the spread in each of the last five games between South Florida and Memphis.
• Memphis has failed to cover the spread in each of its last four home games against teams from Florida.

Total Points Facts

• Eleven of South Florida’s last 12 road games against conference opponents have gone OVER the total points line.
• Four of Memphis’ last five games as an underdog have gone OVER the total points line.

Matchup/League Facts

• Memphis has recorded the equal-most home wins by a margin of three points or less of any FBS team this season (1).
• Memphis ranks T3rd among FBS teams for average point differential in fourth quarters this season (+7.3).
• South Florida has recorded the equal-most home wins by a margin of 15+ points of any FBS team this season (4).
• South Florida has recorded the equal-most home wins by a margin of 20+ points of any FBS team this season (4).

Memphis vs South Florida Prediction 

This was shaping up to be a huge battle that could potentially decide a spot in the CFP, but Memphis choked last week and is dealing with an injury to their quarterback. The Tigers picked up a terrible loss to UAB and their defense was not good. South Florida has rolled through their first three conference games and they have scored 48, 63, and 54 points in those three wins. The Bulls may not play the best defense, but their offense is electric and should move the ball very easily here. Take South Florida to cover. 

David Racey is 80-61 (57%) in College Football this season and is one of the top College Football Handicappers on the site. Click here for his premium plays for the week!