Minnesota vs Ohio State Prediction 10/4/25 College Football Picks Today

In this article, we will formulate a Minnesota vs Ohio State Prediction for this College Football Week 6 game on Saturday, October 4^th at the Ohio Stadium. Let’s take a look at the prediction for this College Football matchup.

Ohio State Preview

Ohio State has a 4-0 record this season and is sitting on the 4^th place of the Big 10. They are 3-0-1 ATS, 1-3 in Over/Under and have a 1-0 away record and 3-0 home record. The Buckeyes are coming off a 24-6 road win at Washington and are playing Illinois and Wisconsin next.

Offensively, the Buckeyes average 36.2 points per game, which ranks 37th in the nation. Defensively, they allow 5.5 points per game, which is 1st. Ohio State averages 445.8 total yards per game, with 181.3 rushing yards and 264.5 passing yards per game. They allow 229.3 total yards per game, with 97.3 rushing and 132.0 passing yards per game.

Julian Sayin leads the Buckeyes with 987 passing yards and 78.8% completed passes. Bo Jackson leads the team in rushing yards, with 297, while Jeremiah Smith has a team-high 28 caught passes for 396 receiving yards, and has 4 touchdowns. Defensively, Caden Curry has a team-high 25 total tackles, 16 of them solo. Caden Curry leads the Buckeyes in sacks, with 5, while Caleb Downs has one interception.

Minnesota Preview

Minnesota has a 3-1 record this season and is sitting on the 6^th place of the Big 10. They are 1-3 ATS, 3-1 in Over/Under and have a 0-1 away record and 3-0 home record. The Golden Gophers are coming off a 31-28 home win vs Rutgers and are playing Purdue and Nebraska next.

Offensively, the Golden Gophers average 33.5 points per game, which ranks 50th in the nation. Defensively, they allow 16.2 points per game, which is 26th. Minnesota averages 405.3 total yards per game, with 144.0 rushing yards and 261.3 passing yards per game. They allow 230.0 total yards per game, with 65.5 rushing and 164.5 passing yards per game.

Drake Lindsey leads the Golden Gophers with 958 passing yards and 65.8% completed passes. Fame Ijeboi leads the team in rushing yards, with 173, while Kenric Lanier II has a team-high 12 caught passes for 204 receiving yards, and has 2 touchdowns. Defensively, Devon Williams has a team-high 31 total tackles, 13 of them solo. Anthony Smith leads the Golden Gophers in sacks, with 4.5, while Kerry Brown has two interceptions.

Minnesota Golden Gophers @ Ohio State Buckeyes Betting Trends: Week 6

Why the Ohio State Buckeyes will win

• Ohio State has won each of its last 26 home games in October.
• Minnesota has lost 25 of its last 31 games against AP-ranked teams.
• Ohio State has covered the spread in seven of its last eight games.
• Minnesota has failed to cover the spread in four of its last five games against teams from Ohio.
• Ohio State has won the first quarter in six of its last seven home games against conference opponents.
• Ohio State has won the first half in 24 of its last 26 games against conference opponents at Ohio Stadium.

Why the Minnesota Golden Gophers will win

• Minnesota has won each of its last five games in October.
• Minnesota has covered the spread in each of its last five games in October.
• Ohio State has failed to cover the spread in three of its last four games in October.
• Minnesota has won the first quarter in five of its last six games against conference opponents.

Total Points Facts

• Eight of Ohio State’s last nine home games against conference opponents have gone UNDER the total points line.
• Five of Minnesota’s last six games against top-10 AP-ranked teams have gone OVER the total points line.

Ohio State Buckeyes Player Prop Facts

• Jeremiah Smith has recorded 75+ receiving yards in three consecutive games – equal-longest streak in the FBS, heading into Week 6.

Minnesota Golden Gophers Player Prop Facts

• Heading into Week 6, Anthony Smith ranks T9th amongst FBS players for sacks (4.5) this season.

Matchup/League Facts

• Ohio State ranks 1st among FBS teams for points allowed per game this season (5.5).
• Ohio State ranks T1st among FBS teams for Q1 opponent points per game this season (0.0).
• Minnesota has recorded the equal-most home wins by a margin of five points or less of any FBS team this season (1).
• Minnesota has recorded the equal-most home wins by a margin of three points or less of any FBS team this season (1).

Minnesota vs Ohio State Prediction

In their previous meeting in 2023, Ohio State won 37-3 at home. They have won their last 10 meetings against Minnesota, but Minnesota is 3-2 against the spread in their last 5 meetings. Under is 4-1 in their last 5 meetings.

In this Minnesota vs Ohio State Prediction, Ohio State is coming as -23.5-point home favorites, with the total set at 44.5 points. Ohio State has been one of the strongest squads in the nation so far in this young season, as they have won and covered all of their four games played. They have the best defense in the nation, holding their opponents into just 5.5 points per game, and winning by an average of 30.7 points. The Buckeyes have been dominating Minnesota historically, and I expect them to continue to do so today. Take Ohio State and lay the -23.5 points at home in this one.