
Missouri State vs SMU Prediction Football Picks Today 9/13/25
SMU Mustangs (1-1) vs. Missouri State Bears (1-1)
September 13, 2025 3:30 pm EDT
The Line: Missouri State Bears +28 / SMU Mustangs -28; Over/Under: 61.5
(Get latest betting odds)
The SMU Mustangs and the Missouri State Bears meet in week 3 college football action from Robert W. Plaster Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s an SMU Mustangs vs. Missouri State Bears prediction.
SMU Mustangs Recap
The SMU Mustangs come into this game looking to rebound from a 48-45 loss at the hands of Baylor last time out to sit at 1-1 on the year. After this game, SMU will head on the road for a game against TCU.Â
Mustangs Looking To Rebound From Upset Loss
Kevin Jennings has thrown for 555 yards, 5 touchdowns and 2 interceptions on 73.1% passing while T.J. Harden has rushed for a team-high 157 yards and 3 touchdowns this season. Romello Brinson leads SMU in receiving with 11 catches for 247 yards and 3 touchdowns while Jalen Cooper has 7 grabs for 162 yards and a pair of touchdowns as well on the year. On defense, Isaiah Nwokobia has a team-high 17 total tackles while the SMU defense as a whole has combined for four sacks and a pair of interceptions so far this season.
Why the SMU Mustangs will win
- SMU has won eight of its last nine games against non-AP-ranked teams.
- SMU has covered the spread in four of its last five games against opponents from the Conference USA.
Missouri State Bears Recap
The Missouri State Bears will be out to build on their 21-20 win over Marshall last time out to sit at 1-1 this season. After this game, Missouri State will have a home matchup with Tennessee-Martin.
Bears Looking For Massive Upset Win
Jacob Clark has thrown for 506 yards, 4 touchdowns and 3 interceptions on 67.3% passing while Shomari Lawrence leads the Bears on the ground with 99 rushing yards. Ramone Green Jr. has a team-high 151 receiving yards and 6 receptions with a touchdown while Jmariyae Robinson has 6 receptions as well for 115 yards and a touchdown. On defense, Jared Lloyd and Maguire Neal each have a team-high 12 total tackles, while Mitchell Toney has a pair of sacks and Kanye Young has an interception for the Missouri State defense this season.
Why the Missouri State Bears will win
- SMU has lost each of its last three road games in September.
- SMU has failed to cover the spread in each of its last four games.
Total Points Facts
- Each of SMU’s last four road games in September have gone UNDER the total points line.
SMU Mustangs vs. Missouri State Bears Prediction
I’m on the Mustangs here. Missouri State had a nice showing last time out to get their first win at the FBS level, but going from a narrow win over a depleted Marshall team, to a team that made the college football playoff last year, even at home (which is still surprising to me that SMU made the trip to Missouri State), is too much of a jump for me to think Missouri State competes here. I think SMU runs away early in this one so give me SMU here in a blowout.