Missouri vs Alabama Prediction Football Picks Today 10/11/25
Alabama Crimson Tide (4-1) vs. Missouri Tigers (5-0)
October 11, 2025 12:00 pm EDT
The Line: Missouri Tigers 3 / Alabama Crimson Tide -3; Over/Under: 52.5
(Get latest betting odds)
The Alabama Crimson Tide and Missouri Tigers meet Saturday in college football action at Memorial Stadium. Here’s a Missouri vs Alabama Prediction. This article will include a Missouri vs Alabama Pick.
Alabama Crimson Tide Betting Preview
The Alabama Crimson Tide beat Georgia and Vanderbilt, and they play Tennessee next. Alabama has won 4 straight games. Ty Simpson is completing 70.3 percent of his passes for 1,478 yards, 13 touchdowns, and 1 interception. Germie Bernard and Ryan Williams have combined for 728 receiving yards and 8 touchdowns, while Isaiah Horton has 18 receptions.
The Alabama Crimson Tide ground game is averaging 126.8 yards per contest, and Jam Miller leads the way with 182 yards and 1 touchdown. Defensively, Alabama is allowing 16 points and 285.8 yards per game. Justin Jefferson leads the Alabama Crimson Tide with 29 tackles, LT Overton has 1.5 sacks and Bray Hubbard has 2 interceptions.
Missouri Tigers Betting Preview
The Missouri Tigers beat South Carolina and UMASS, and they play Auburn next. The Missouri Tigers have won 8 straight games. Beau Pribula is completing 75.9 percent of his passes for 1,203 yards, 9 touchdowns, and 3 interceptions. Marquis Johnson and Kevin Coleman Jr. have combined for 661 receiving yards and 3 touchdowns, while Brett Norfleet has 20 receptions.
The Missouri Tigers ground game is averaging 292 yards per contest, and Ahmad Hardy leads the way with 730 yards and 9 touchdowns. Defensively, Missouri is allowing 14.6 points and 203.8 yards per game. Josiah Trotter leads the Missouri Tigers with 28 tackles, Damon Wilson II has 3.5 sacks and Dante McClellan has 1 interception.
Missouri Tigers Player Prop Facts
- Heading into Week 7, Ahmad Hardy ranks 1st amongst FBS players for rushing yards (730) this season.
Alabama Crimson Tide Player Prop Facts
- Heading into Week 7, Bray Hubbard leads the Southeastern Conference for interceptions (2) this season.
Matchup/League Facts
- Missouri has recorded the equal-most home wins by a margin of 10+ points of any FBS team this season (4).
- Missouri has recorded the equal-most home wins by a margin of 15+ points of any FBS team this season (3).
- Alabama has recorded the equal-most home wins by a margin of 15+ points of any FBS team this season (3).
- Alabama ranks 5th among FBS teams for passing yards per game this season (325.4).
Missouri vs Alabama Prediction
Missouri is playing high level ball on both sides of the ball and has had an extra week to prepare. Those who have followed along over the years know I love my dogs that have the rest advantage. However, Missouri hasn’t had the toughest schedule up to this point, so the jury is still out for me. Just how good is Missouri really? Guess we’ll find out here.
Alabama has been a different team since that opening loss to FSU, and its back-to-back wins over Georgia and Vanderbilt should turn heads. Alabama is back to being strong defensively, and its passing attack has been elite. This is a spot we don’t get Alabama often, as it’s just the seventh time since 2007 where the Tide are favorites of 3 or fewer points. I’d need more to give Missouri a look. Give me Alabama and the small number.