
Missouri vs Kansas Prediction Football Picks Today 9/6/25
Kansas Jayhawks (2-0) vs. Missouri Tigers (1-0)
September 6, 2025 3:30 pm EDT
The Line: Missouri Tigers -6 / Kansas Jayhawks +6; Over/Under: 50.5
(Get latest betting odds)
The Kansas Jayhawks and the Missouri Tigers meet in week 2 college football action from Memorial Stadium at Faurot Field on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Kansas Jayhawks vs. Missouri Tigers prediction.
Kansas Jayhawks Recap
The Kansas Jayhawks come into this game looking to build on their 2-0 start to the year after a 46-7 win over Wagner last time out. After this game, the Jayhawks will head home for a game against West Virginia following a bye week.
Jayhawks Looking To Pick Up Another 3-0 Start
Jason Daniels has thrown for 456 yards, 7 touchdowns and an interception 80% passing while Daniel Hishaw Jr. leads Kansas in rushing with 158 rushing yards and a touchdown. Emmanuel Henderson Jr. leads Kansas with 9 receptions for 154 yards and 2 touchdowns while Cam Pickett has 8 receptions for 106 receiving yards and 3 touchdowns this season. On defense, Trey Lathan has a team-high 12 total tackles including 6 solo tackles while Lyric Rawls has 7 solo tackles and an interception. Leroy Harris III and D.J Withers each have a team-high 2 sacks while Devin Dye has an interception on the year.
Why the Kansas Jayhawks will win
- Kansas has won each of its last three games as an underdog.
- Kansas has covered the spread in each of its last four games as an underdog.
Missouri Tigers Recap
The Missouri Tigers come into this game looking to build on their 61-6 beatdown win over Central Arkansas to start the year 1-0. After this game, the Tigers will square off against the Louisiana Ragin’ Cajuns at home.
Tigers Looking To Start Season With Run Before SEC Play
Beau Pribula threw for 283 yards and 2 touchdowns while also rushing for 65 yards and 2 more scores on the ground. Matt Zollers threw for 58 yards and a touchdown on 3 of 3 passing while Ahmad Hardy had a team-high 100 rushing yards and a touchdown on 10 carries. Marquise Davis also had a rushing TD as well for the Tigers in the win. Marquis Johnson led Mizzou with 5 grabs for 134 yards and a touchdown while Joshua Manning had 4 receptions for 53 yards and Kevin Coleman added 6 receptions for 48 yards. Jude James and Brett Norfleet each had a touchdown grab as well for the Tigers in victory. On defence, Josiah Trotter led the Tigers with 8 total tackles while Jeremiah Beasley had a team-high 7 solo tackles. Damon Wilson II added a pair of sacks and Dante McClellan chipped in an 83-yard pick-six for the Missouri defense in the win.Â
Why the Missouri Tigers will win
- Missouri has won each of its last 20 games against non-conference opponents at Faurot Field at Memorial Stadium.
- Kansas has lost each of its last five games in September.
- Missouri has covered the spread in each of its last seven games against non-AP-ranked teams.
- Kansas has failed to cover the spread in each of its last five games in September.
Total Points Facts
- Each of Kansas’ last 10 September games as an underdog against non-AP-ranked teams have gone OVER the total points line.
- Five of Missouri’s last six games have gone OVER the total points line.
Kansas Jayhawks vs. Missouri Tigers Prediction
I’m on Missouri here. I’d be lying if I said I wasn’t impressed with what Jalon Daniels has done to start the year, but going on the road into SEC country against a rock solid Missouri lineup. The Tigers looked dominant offensively and this is still a really strong Missouri defense that’s a step up in competition in a massive way. Give me Missouri here.