Nebraska vs USC Prediction Football Picks Today 11/1/25

The USC Trojans and the Nebraska Cornhuskers meet in week 10 college football action from Memorial Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a USC Trojans vs. Nebraska Cornhuskers prediction.

USC Trojans Recap

The USC Trojans come into this game looking to bounce back from a 34-24 loss at the hands of Notre Dame prior to last week’s bye week to sit at 5-2 this season. After this game, USC will head home for a game against Northwestern.

Trojans Alternate Wins & Losses In 4 Straight Games

Jayden Maiava has thrown for 2,180 yards, 15 touchdowns and 4 interceptions on 68.1% passing while Husan Longstreet’s thrown for 103 yards and a TD on 86.7% passing. Waymond Jordan leads USC in rushing with 576 yards and 5 TDs while King Miller has 380 rushing yards and 3 touchdowns as well. Eli Sanders has 264 rushing yards and he and the aforementioned Longstreet each have a pair of rushing TDs as well. Makai Lemon leads the Trojans in receiving with 48 catches for 758 yards and 6 touchdowns while Ja’Kobi Lane has 424 receiving yards and 3 TDs and Lake McRee has 307 receiving yards as well as a touchdown. Three more USC receivers have 100+ receiving yards as well this season. On defense, Eric Gentry has a team-high 48 solo tackles while also logging 3 sacks. Bishop Fitzgerald has a team-high 5 interceptions while Devan Thompkins has 3 sacks, Kameryn Crawford and Braylan Shelby each have a team-high 3.5 sacks. As a unit, USC has combined for 21 sacks and 8 interceptions so far this season.

Why the USC Trojans will win

• Nebraska has lost each of its last 28 games against AP-ranked teams.
• USC has won each of its last seven games against non-AP-ranked teams.
• Nebraska has failed to cover the spread in each of its last seven home games against AP-ranked teams.
• USC has covered the spread in three of its last four road games in November.

Nebraska Cornhuskers Recap

The Nebraska Cornhuskers come into this game looking to add on to their 28-21 win over Northwestern last time out to sit at 6-2 this season. After this game, Nebraska will head on the road for a game against the UCLA Bruins.

Cornhuskers Win 3 Of Last 4

Dylan Raiola has thrown for 1,909 yards, 17 touchdowns and 6 interceptions on 72.8% passing while Emmett Johnson leads the Cornhuskers in rushing with 837 yards on the ground along with 9 touchdowns and Kwinten Ives has 119 rushing yards and 2 TDs as well this season. Nyziah Hunter has a team-high 33 catches for 525 yards and 5 touchdowns while Jacory Barney Jr. has 378 receiving yards and 3 TDs. Dane Key has 291 receiving yards and 4 TDs and Luke Lindenmeyer has 263 receiving yards and 2 TDs while four more Cornhuskers have 100+ receiving yards as well this season. On defense, Javin Wright has a team-high 52 total tackles while Dasan McCullough has a team-high 2 sacks so far this season. As a unit, Nebraska’s defense has combined for 12 sacks and 5 interceptions so far this season. 

Why the Nebraska Cornhuskers will win

• USC has lost five of its last seven games as a road favorite.
• The home team has won each of USC’s last four games.
• USC has failed to cover the spread in nine of its last 10 games as a road favorite.
• Nebraska has covered the spread in five of its last six November games as a home underdog.

Total Points Facts

• Each of Nebraska’s last seven games at Memorial Stadium (Lincoln) have gone OVER the total points line.
• Each of USC’s last five November road games against non-AP-ranked teams have gone UNDER the total points line.

USC Trojans vs. Nebraska Cornhuskers Prediction

I’m on USC here. I know USC has had issues with these cross-country travel spots in the last couple of seasons, but I think they’re still the better team here with the better offense and USC’s defense has been able to get in the backfield which is problematic for Nebraska, who has gone into the bottom-10 in sacks allowed this season. I think even on the road, USC wins by a touchdown so I’ll lay the points with the Trojans here.