Wyoming Cowboys (2-2) vs. North Dakota State Bison (4-0)
October 3, 2026 3:30 pm EDT
The Line: North Dakota State Bison -17.5 / Wyoming Cowboys +17.5; Over/Under: 44.5
(Get latest betting odds)
The Wyoming Cowboys and the North Dakota State Bison meet in week 5 college football action from the Fargodome on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Wyoming Cowboys vs. North Dakota State Bison Prediction.
Wyoming Cowboys Recap
The Wyoming Cowboys come into this game looking to build on their 27-10 win over Hawaii last time out to sit at 2-2 this season. After this game, Wyoming will head on the road for a game against San Jose State.
Cowboys Alternate Wins & Losses To Start Year
Tyler Hughes has thrown for 656 yards, 2 touchdowns and 5 interceptions on 62.2% passing while Samuel Harris leads Wyoming in rushing with 226 yards and 2 touchdowns so far this season. Markell Holman sits behind Harris on the ground with 219 yards and 3 TDs. Kyle Frendt leads the Cowboys in receiving with 155 yards and 8 catches along with 1 TD, while Jake Wilson trails with 144 yards and 11 catches. On defense, Gary Rutherford has a team-high 30 tackles while Wyoming’s defense as a whole has combined for 6 sacks and 2 interceptions so far this season.
North Dakota State Bison Recap
The North Dakota State Bison come into this game looking to add on to their 31-10 win over Sacramento State last time out to sit at 4-0 this season. After this game, the Bison will head on the road for a game against UNLV.
Bison Looking To Stay Unbeaten
Nathan Hayes has thrown for 808 yards, 7 touchdowns and 2 interceptions on 67.0% passing while DJ Scott leads North Dakota State in rushing with 225 yards and 3 touchdowns so far this season. Myles Mitchell sits behind Scott on the ground with 214 yards and 3 TDs. Jackson Williams leads the Bison in receiving with 283 yards and 18 catches along with 1 TD, while Mekhi Collins trails with 134 yards and 7 catches. On defense, Donovan Woolen has a team-high 24 tackles while North Dakota State’s defense as a whole has combined for 7 sacks and 7 interceptions so far this season.
Wyoming Cowboys @ North Dakota State Bison Betting Trends: Week 5
Why the North Dakota State Bison will win
- Wyoming has lost each of its last seven road games.
- The home team has won 10 of Wyoming’s last 11 games.
- Wyoming has failed to cover the spread in seven of its last eight games.
- The home team has covered the spread in four of Wyoming’s last five games.
- North Dakota State has won the first quarter in each of its last three games.
- Wyoming has lost the first half in seven of its last eight games.
Why the Wyoming Cowboys will win
- Wyoming has covered the spread in five of its last six games in October.
- The underdog has won the first half in each of Wyoming’s last three games.
Total Points Facts
- Each of Wyoming’s last seven games against conference opponents have gone UNDER the total points line.
- Three of North Dakota State’s last four games have gone UNDER the total points line.
North Dakota State Bison Player Prop Facts
- Heading into Week 5, Jackson Williams ranks 1st in the Mountain West Conference for receiving yards (283) this season.
Wyoming Cowboys Player Prop Facts
- Heading into Week 5, Kyle Frendt ranks T1st amongst qualified players for catch rate (100.0%) this season.
Matchup/League Facts
- North Dakota State ranks T1st among FBS teams for Q3 opponent points per game this season (0.0).
- North Dakota State ranks 1st among FBS teams for red zone percentage against this season (55.6).
- Wyoming ranks T134th among FBS teams for H1 points per game this season (6.5).
- Wyoming ranks 132nd among FBS teams for points per game this season (17.8).
Wyoming Cowboys vs. North Dakota State Bison Prediction
I’m on North Dakota State in this one. I get the case to be made for a team like Wyoming catching a boatload of points, but the thing is that North Dakota State is still so much the better team and Wyoming has gotten drilled in their road contests so far this season. I think this is a situation where Wyoming gets run all over by North Dakota State and the Bison smack around the Cowboys in a comfortable win. Give me North Dakota State.
