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Notre Dame vs Pitt Prediction 11/15/25 College Football Picks Today

Notre Dame vs Pitt
November 15, 2025 12:00 pm EDT
The Line: Notre Dame -12.5 / Over/Under: 55.5
(Get latest betting odds)

In this article, we will formulate a Notre Dame vs Pitt Prediction for this College Football Week 12 game on Saturday, November 15th. Let’s take a look at the prediction for this College Football matchup.

Pitt Panthers Preview

Pitt has a 7-2 record this season and is sitting 3rd in the ACC. They are 7-2-0 ATS, 6-3-0 in Over/Under and have a 4-1 home record and a 3-1 away record. Pitt is coming off a 35-20 road win against Stanford and will face Georgia Tech and Miami (FL) next.

Offensively, Pitt averages 39.7 points per game, ranking 6th in the nation, while defensively, they allow 21.8 points per game, which is 43rd. Pitt averages 426.8 total yards per game (302.6 passing and 124.2 rushing), while allowing 318.3 total yards per game (80.9 rushing and 237.4 passing).

Mason Heintschel leads Pitt with 1,547 passing yards with 64.1% completed passes and 12 touchdowns. Ja’Kyrian Turner leads the team in rushing yards with 399, while Kenny Johnson has a team-high 37 receptions for 573 receiving yards. Defensively, Braylan Lovelace has a team-high 55 total tackles (24 of them solo), while Jimmy Scott leads the team in sacks, with 4, and Kyle Louis, Shawn Lee Jr. have a team-high 2 interceptions each.

Notre Dame Fighting Irish Preview

Notre Dame has a 7-2 record this season and is sitting 1st in the IA Independents. They are 4-4-1 ATS, 5-4-0 in Over/Under and have a 5-1 home record and a 2-1 away record. Notre Dame is coming off a 49-10 home win against Navy and will face Syracuse and Stanford next.

Offensively, Notre Dame averages 38.7 points per game, ranking 9th in the nation, while defensively, they allow 18.8 points per game, which is 18th. Notre Dame averages 466.1 total yards per game (271.7 passing and 194.4 rushing), while allowing 334.9 total yards per game (102.6 rushing and 232.3 passing).

CJ Carr leads Notre Dame with 2,275 passing yards with 67.6% completed passes and 19 touchdowns. Jeremiyah Love leads the team in rushing yards with 988, while Jordan Faison has a team-high 43 receptions for 545 receiving yards. Defensively, Drayk Bowen has a team-high 55 total tackles (25 of them solo), while Boubacar Traore leads the team in sacks, with 6.5, and Tae Johnson, Luke Talich have a team-high 3 interceptions each.

Notre Dame Fighting Irish @ Pittsburgh Panthers Betting Trends: Week 12

 

Why the Pittsburgh Panthers will win

  • Pittsburgh has won seven of its last eight home games against non-conference opponents.
  • Notre Dame has lost three of its last four games against AP-ranked teams.
  • Pittsburgh has covered the spread in each of its last five games.
  • Notre Dame has failed to cover the spread in each of its last four games against AP-ranked teams.
  • Pittsburgh has won the first quarter in 10 of its last 11 home games against non-conference opponents.
  • Pittsburgh has won the first half in four of its last five home games against non-conference opponents.

Why the Notre Dame Fighting Irish will win

  • Notre Dame has won each of its last eight games in November.
  • Pittsburgh has lost each of its last seven November games as an underdog.
  • Notre Dame has covered the spread in seven of its last eight games in November.
  • The team ranked 23rd in the AP Poll has failed to cover the spread in each of its last four games.
  • Notre Dame has won the first half in eight of its last nine games against opponents from the Atlantic Coast Conference.

Total Points Facts

  • Each of Pittsburgh’s last eight home games against non-conference opponents have gone OVER the total points line.
  • Twelve of Notre Dame’s last 14 games in November have gone OVER the total points line.

Pittsburgh Panthers Player Prop Facts

  • Heading into Week 12, Trey Butkowski ranks T2nd amongst FBS players for made field goals (19) this season.

Notre Dame Fighting Irish Player Prop Facts

  • Heading into Week 12, Jeremiyah Love ranks T1st amongst FBS players for touchdowns (16) this season.

Matchup/League Facts

  • Pittsburgh ranks 3rd among FBS teams for rushing yards allowed per game this season (80.9).
  • Pittsburgh ranks T4th among FBS teams for Q2 points per game this season (13.7).
  • Notre Dame has won the third quarter in each of its last eight games – longest active streak in the FBS.
  • Notre Dame has recorded more total yards than its opponents in each of its last seven games – longest active streak in the FBS.

Notre Dame vs Pitt Prediction

In this Notre Dame vs Pitt Prediction, Notre Dame is coming as -12.5-point road favorites, with the total set at 55.5 points. Both teams have identical overall records and both have been red-hot lately, with 5 and 7 consecutive wins each. Both teams have top-10 offenses in the country, scoring 88.4 points per game combined. Their previous meeting in 2023 had 65 total points and the over is 3-1 in their last 4 meetings. I expect a high-scoring affair, so take the over 55.5 in this one.

Nikos Lagouretos's Free Pick: Over 55.5

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