Missouri Tigers (7-3) vs. Oklahoma Sooners (8-2)
November 22, 2025 12:00 pm EDT
The Line: Oklahoma Sooners -6.5 / Missouri Tigers +6.5; Over/Under: 42.5
(Get latest betting odds)
The Missouri Tigers and the Oklahoma Sooners meet in week 13 college football action from Memorial Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Oklahoma vs Missouri Prediction.
Missouri Tigers Recap
The Missouri Tigers come into this game looking to build on their 49-27 win over Mississippi State last time out to sit at 7-3 this season. After this game, Missouri will head on the road one more time to close out the regular season against Arkansas.
Tigers Looking To Build Momentum
Beau Pribula has thrown for 1,685 yards, 11 touchdowns, and 7 interceptions on 69.6% passing but will miss the rest of the season with an injury. Matt Zollers has 402 passing yards, 4 TDs, and an INT on 53% passing. Ahmad Hardy leads Missouri in rushing with 1,346 yards and 15 touchdowns. Jamal Roberts has rushed for 583 yards and 4 touchdowns while Marquise Davis has 200 rushing yards with 2 TDs and Pribula has 182 rushing yards and 4 touchdowns. Kevin Coleman Jr. has a team-high 56 catches for 600 yards while Marquis Johnson has 340 receiving yards and Donovan Olugbode has 22 grabs for 318 yards and 3 touchdowns. On defense, Josiah Trotter has a team-high 61 total tackles while Damon Wilson II has a team-high 7 sacks. Zion Young has 5.5 sacks and Khalil Jacobs also has 3 sacks so far this season. As a unit, Missouri’s defense has combined for 29 sacks and 7 interceptions so far this season.
Why the Missouri Tigers will win
- The underdog has won each of Oklahoma’s last three games.
- The road team has covered the spread in each of Oklahoma’s last four games.
Oklahoma Sooners Recap
The Oklahoma Sooners come into this game looking to build on their 23-21 win over Alabama last time out to sit at 8-2 this season. After this game, Oklahoma will take on LSU at home to close out the regular season.
Sooners Win Back-To-Back Games
John Mateer has thrown for 2,087 yards, 8 touchdowns and 7 interceptions on 63.9% passing while also rushing for 329 yards and 7 touchdowns and Tory Blaylock also has a team-high 402 rushing yards and 4 TDs while Xavier Robinson has 366 rushing yards and 4 TDs as well this season. Isaiah Sategna III has a team-high 53 receptions for 718 yards and 5 TDs while Jaren Kanak has 433 receiving yards. Deion Burks has 454 receiving yards and Keontez Lewis has 226 receiving yards as well this season. On defense, Kip Lewis has a team-high 60 total tackles while R Mason Thomas has a team-high 6.5 sacks and Taylor Wein has 4.5 sacks. Jayden Jackson and Gracen Halton each have 3 sacks as well for Oklahoma this season. As a unit, Oklahoma has combined for 37 sacks and 6 interceptions this season.
Why the Oklahoma Sooners will win
- Oklahoma has won 18 of its last 19 home games in November.
- Missouri has lost each of its last six games against AP-ranked teams.
- Oklahoma has covered the spread in eight of its last nine home games in November.
Total Points Facts
- Each of Oklahoma’s last seven November home games against AP-ranked teams have gone UNDER the total points line.
- Seven of Missouri’s last eight games in November have gone OVER the total points line.
Oklahoma vs Missouri Prediction
I’m on Oklahoma here. I just think Oklahoma has everything to play for here, needing to deliver strong showings in their final two games to make a case to the playoff committee that they deserve to be in the field. We saw Zollers struggle for Missouri against Texas A&M and this Oklahoma defense is just as, if not more, ferocious than Texas A&M’s. Give me the Sooners here.
