Ole Miss Rebels (6-1) vs. Oklahoma Sooners (6-1)
October 25, 2025 12:00 pm EDT
The Line: Oklahoma Sooners -4.5 / Ole Miss Rebels 4.5; Over/Under: 54.5
(Get latest betting odds)
The Ole Miss Rebels and Oklahoma Sooners meet Saturday in college football action at Memorial Stadium. Here’s a Oklahoma vs Ole Miss Prediction. This article will include a Oklahoma vs Ole Miss Pick.
Ole Miss Rebels Betting Preview
The Ole Miss Rebels beat Washington State, lost to Georgia, and they play South Carolina next. The Ole Miss Rebels have won 8 of their last 9 games. Trinidad Chambliss is completing 62.7 percent of his passes for 1,549 yards, 8 touchdowns, and 1 interception. Harrison Wallace III and Dae’Quan Wright have combined for 793 receiving yards and 5 touchdowns, while Deuce Alexander has 22 receptions.
The Ole Miss Rebels ground game is averaging 187.7 yards per contest, and Kewan Lacy leads the way with 618 yards and 10 touchdowns. Defensively, Ole Miss is allowing 22.6 points and 362.3 yards per game. TJ Dottery leads the Ole Miss Rebels with 46 tackles, Will Echoles has 3 sacks and Wydett Williams Jr. has 1 interception.
Oklahoma Sooners Betting Preview
The Oklahoma Sooners lost to Texas, beat South Carolina, and play Tennessee next. Oklahoma has won 6 of its last 7 games. John Mateer is completing 64.9 percent of his passes for 1,567 yards, 7 touchdowns, and 6 interceptions. Isaiah Sategna III and Jaren Kanak have combined for 857 receiving yards and 4 touchdowns, while Deion Burks has 32 receptions.
The Oklahoma Sooners ground game is averaging 122.3 yards per contest, and Tory Blaylock leads the way with 391 yards and 4 touchdowns. Defensively, Oklahoma is allowing 9.8 points and 211.2 yards per game. Kip Lewis leads the Oklahoma Sooners with 31 tackles, R Mason Thomas has 5.5 sacks and Taylor Wein has 1 interception.
Why the Oklahoma Sooners will win
- Oklahoma has won each of its last 14 games as a favorite against top-15 AP-ranked teams.
- Ole Miss has lost each of its last nine October road games against AP-ranked teams.
- Ole Miss has failed to cover the spread in each of its last six October games against AP-ranked teams.
- Oklahoma has covered the spread in each of its last five games as a favorite against top-15 AP-ranked teams.
- Oklahoma has won the first half in 25 of its last 32 games against conference opponents at Oklahoma Memorial Stadium.
Why the Ole Miss Rebels will win
- Ole Miss has won eight of its last nine games.
- Oklahoma has failed to cover the spread in each of its last four October games at Oklahoma Memorial Stadium.
- Ole Miss has won the first half in seven of its last eight games against conference opponents.
Total Points Facts
- Each of Oklahoma’s last eight games have gone UNDER the total points line.
- Seven of Ole Miss’ last eight games in October have gone UNDER the total points line.
Oklahoma Sooners Player Prop Facts
- Heading into Week 9, John Mateer leads Oklahoma for touchdowns (5) this season.
Ole Miss Rebels Player Prop Facts
- Heading into Week 9, Dae’Quan Wright leads the Southeastern Conference for yards per reception (20.7) this season.
Matchup/League Facts
- Oklahoma ranks T1st among FBS teams for Q1 opponent points per game this season (0.4).
- Oklahoma ranks 1st among FBS teams for yards allowed per game this season (213.0).
- Ole Miss has recorded the equal-most home wins by a margin of 10 points or less of any FBS team this season (3).
- Ole Miss has recorded the equal-most home wins by a margin of five points or less of any FBS team this season (2).
Oklahoma vs Ole Miss Prediction
Oklahoma is going to get the benefit of the doubt with that elite defense and being at home. However, Mateer hasn’t been the same quarterback in his first two games back from hand surgery. Ole Miss is also an elite level offense that will test this Sooners defense. Ole Miss made Georgia look silly last week and probably should’ve won that game outright if we’re being honest.
Ole Miss has covered 6 of its last 9 games as an underdog, and 5 of those covers were outright victories. Oklahoma has also had issues running the ball, which would play into the strength of this Rebels defense if forced to pass. Give me the points in what should be a fun SEC back and forth.
