College Football

Old Dominion vs Liberty Prediction Football Picks Today 9/27/25

Liberty Flames (1-3) vs. Old Dominion Monarchs (2-1)
September 27, 2025 6:00 pm EDT
The Line: Old Dominion Monarchs -16 / Liberty Flames 16; Over/Under: 51.5
(Get latest betting odds)

The Liberty Flames and Old Dominion Monarchs meet Saturday in college football action at S.B. Ballard Stadium. Here’s a Old Dominion vs Liberty Prediction. This article will include a Old Dominion vs Liberty Pick.

Liberty Flames Betting Preview

The Liberty Flames lost to James Madison and Bowling Green, and they play UTEP next. The Liberty Flames have lost 5 of their last 6 games. Ethan Vasko is completing 57.3 percent of his passes for 763 yards, 6 touchdowns, and 3 interceptions. Donte Lee Jr. and Jamari Person have combined for 343 receiving yards and 3 touchdowns, while Reese Smith has 12 receptions.

The Liberty Flames ground game is averaging 175.8 yards per contest, and Ethan Vasko leads the way with 297 yards and 2 touchdowns. Defensively, Liberty is allowing 23.8 points and 362.5 yards per game. Derrell Farrar leads the Liberty Flames with 25 tackles, CJ Bazile Jr. has 1.5 sacks and Amarian Williams has 1 interception.

Old Dominion Monarchs Betting Preview

The Old Dominion Monarchs beat North Carolina Central and Virginia Tech, and they play Coastal Carolina next. Old Dominion has won 3 of its last 4 games. Colton Joseph is completing 67.6 percent of his passes for 629 yards, 5 touchdowns, and 3 interceptions. Ja’Cory Thomas and Na’eem Abdul-Rahim Gladding have combined for 333 receiving yards and 3 touchdowns, while Tre’ Brown III has 10 receptions.

The Old Dominion Monarchs ground game is averaging 245 yards per contest, and Colton Joseph leads the way with 291 yards and 4 touchdowns. Defensively, Old Dominion is allowing 19.7 points and 390.7 yards per game. Mario Easterly leads the Old Dominion Monarchs with 26 tackles, Jeremy Mack Jr. has 2 sacks and Jerome Carter has 2 interceptions.

Liberty Flames @ Old Dominion Monarchs Betting Trends: Week 5

Why the Old Dominion Monarchs will win

  • Liberty has lost five of its last six games.
  • Old Dominion has won each of its last three games against opponents from the Conference USA at S.B. Ballard Stadium.
  • Liberty has failed to cover the spread in each of its last six games.
  • Old Dominion has covered the spread in each of its last four games.
  • Old Dominion has won the first quarter in three of its last four games against non-conference opponents.
  • Old Dominion has won the first half in three of its last four games against non-conference opponents.

Why the Liberty Flames will win

  • Old Dominion has lost eight of its last nine games against teams from Virginia.
  • Liberty has won three of its last four games as an underdog in Virginia.
  • Old Dominion has failed to cover the spread in each of its last four home games against teams from Virginia.
  • The road team has covered the spread in five of Old Dominion’s last six games.
  • Liberty has won the first half in eight of its last 10 games against opponents from the Sun Belt Conference.

Total Points Facts

  • Each of Liberty’s last eight games as an underdog against non-AP-ranked teams have gone UNDER the total points line.
  • Each of Old Dominion’s last five games against non-AP-ranked teams have gone OVER the total points line.

Old Dominion Monarchs Player Prop Facts

  • Heading into Week 5, Colton Joseph leads the Sun Belt Conference for yards per carry (9.7) this season.

Liberty Flames Player Prop Facts

  • Heading into Week 5, Donte Lee Jr. leads the Conference USA for yards per reception (23.1) this season.

Matchup/League Facts

  • Old Dominion ranks T1st among FBS teams for 4th down conversion percentage this season (100.0).
  • Old Dominion ranks T1st among FBS teams for red zone percentage this season (100.0).
  • Liberty ranks 131st among FBS teams for rushing yards allowed per game this season (226.8).
  • Liberty ranks T125th among FBS teams for H1 points per game this season (6.8).

Old Dominion vs Liberty Prediction

Liberty entered the season as a CUSA contender and a team that could make a playoff push. It’s been anything but. Liberty is stuck in the mud offensively and can’t stop the run defensively. It’s hard to take Liberty seriously in its current form. Old Dominion is in a letdown spot after beating Virginia Tech, but It’s had an extra week to get that out of its system.

Old Dominion is top-20 in rushing offense and top-40 in scoring offense, so it should have a field day against this Liberty defense. Thick line and while there’s talent on this Liberty roster, I’m just not getting the warm and fuzzies. Give me ODU in a home blowout.

Randy Chambers's Free Pick: Old Dominion Monarchs -16

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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