Old Dominion vs South Florida Prediction Football Picks Today 12/17/25

In this article, we will formulate an Old Dominion vs South Florida Prediction for this College Football StaffDNA Cure Bowl game on Wednesday, December 17^th. Let’s take a look at the prediction for this College Football matchup.

South Florida Bulls Preview

South Florida has a 9-3 record this season and finished 4th in the American. They are coming off a 52-3 home win against Rice. Offensively, South Florida averages 43 points per game, ranking 2nd in the nation, while defensively, they allow 23.3 points per game, which is 56th. South Florida averages 501.7 total yards per game (276.3 passing and 225.4 rushing), while allowing 386.8 total yards per game (134.4 rushing and 252.4 passing).

Byrum Brown leads South Florida with 3,158 passing yards with 66.3% completed passes and 28 touchdowns. Byrum Brown leads the team in rushing yards with 1,008, while Keshaun Singleton has a team-high 50 receptions for 877 receiving yards. Defensively, Mac Harris has a team-high 100 total tackles (51 of them solo), while Mac Harris leads the team in sacks, with 6, and Fred Gaskins, Jarvis Lee and James Chenault lead the team with 2 interceptions each.

Old Dominion Monarchs Preview

Old Dominion has a 9-3 record this season and finished 2nd in the Sun Belt. They are coming off a 27-10 home win against Georgia State. Offensively, Old Dominion averages 32.7 points per game, ranking 29th in the nation, while defensively, they allow 19.2 points per game, which is 21st. Old Dominion averages 460.8 total yards per game (223.8 passing and 236.9 rushing), while allowing 331.4 total yards per game (147.4 rushing and 184.0 passing).

Colton Joseph leads Old Dominion with 2,624 passing yards with 59.7% completed passes and 21 touchdowns. Colton Joseph leads the team in rushing yards with 1,007, while Ja’Cory Thomas has a team-high 38 receptions for 674 receiving yards. Defensively, Jerome Carter has a team-high 72 total tackles (33 of them solo), while Jeremy Mack leads the team in sacks, with 4.5, and Jerome Carter has a team-high 4 interceptions.

Why the South Florida Bulls will win

• South Florida has won each of its last 11 games as a favorite in Florida.
• Old Dominion has failed to cover the spread in each of its last four games against opponents from the American Conference.
• South Florida has covered the spread in six of its last seven games as a favorite in Florida.

Why the Old Dominion Monarchs will win

• Old Dominion has won each of its last five games.
• Old Dominion has covered the spread in four of its last five games against non-conference opponents.
• Old Dominion has won the first half in four of its last five games against non-conference opponents.

Total Points Facts

• Each of Old Dominion’s last five games have gone UNDER the total points line.
• Five of South Florida’s last six games in December have gone OVER the total points line.

South Florida Bulls Player Prop Facts

• Byrum Brown has recorded a 110.0+ passer rating in four consecutive games (including postseason) – equal-longest streak in the FBS.

Old Dominion Monarchs Player Prop Facts

• Heading into the bowl games, Colton Joseph has recorded the equal-longest passing touchdown in a single game this season (98 yards vs James Madison Dukes, Week 8).

Matchup/League Facts

• South Florida has recorded the equal-most home wins by a margin of 25+ points of any FBS team this season (6).
• South Florida ranks 1st among FBS teams for H2 points per game this season (22.9).
• Old Dominion ranks 2nd among FBS teams for 4th down conversion percentage against this season (28.6).
• Old Dominion ranks 6th among FBS teams for average point differential in first quarters this season (+6.7).

Old Dominion vs South Florida Prediction

In this Old Dominion vs South Florida Prediction, South Florida is coming as -3.5-point favorites. Both teams have identical overall records this season but South Florida has been extremely strong against the spread, with a 9-3 record. Old Dominion is also coming into this matchup in very good form, having won its last five games and is 3-1 against the spread in its last 4, so I will take a pass on the side here. Taking a look at the total, both teams are 7-0 to the under in their last 7 games combined and play very good defense this season, allowing just 42.5 points per game combined. With the total set at 53.5 points, I will go under that number in this matchup.