LSU Tigers (4-0) vs. Ole Miss Rebels (4-0)
September 27, 2025 3:30 pm EDT
The Line: Ole Miss Rebels -1.5 / LSU Tigers 1.5; Over/Under: 57
(Get latest betting odds)
In this article we will formulate an Ole Miss vs LSU prediction for this College Football game on Saturday, September 27th at Vaught-Hemingway Stadium in Oxford, Mississippi. Let’s take a look at the prediction for this week 5 matchup.
Ole Miss Rebels Betting Preview
The Ole Miss Rebels are 4-0 (2-0) this year after they defeated Tulane by a score of 45-10 last week. Ole Miss led 10-0 after the first quarter and 23-3 at halftime, before adding 22 points in the fourth quarter for the blowout win. The Rebels out gained Tulane by a total of 548-282, went 7-11 on third downs, and tied the turnover battle at one each. Trinidad Chambliss went 17-27 for 307 yards and two touchdowns, while also rushing for 112 yards on 14 carries in the game. Deuce Alexander led the receivers with four catches for 94 yards and one score. The Ole Miss defense recorded zero sacks and five tackles for loss in the win.
Ole Miss also has wins against Georgia State, Kentucky, and Arkansas so far this year. The Rebels are averaging 44.8 points per game with 324.8 passing yards and 218.5 rushing yards per game, while they are allowing 18.8 points against per game this season. Trinidad Chambliss has completed 67.7% of his passes for 719 yards and four touchdowns, while Harrison Wallace III has caught 16 passes for 343 yards and two scores. Kewan Lacy has led the ground game for Ole Miss with 358 yards and seven touchdowns on 79 carries this year.
LSU Tigers Betting Preview
The LSU Tigers are 4-0 (1-0) this season after they defeated SELA by a score of 56-10 in their last game. LSU led 7-0 after the first quarter and 35-0 at halftime, before cruising to the win in the second half. The Tigers out gained SELA by a total of 530-205, went 9-14 on third downs, and tied the turnover battle at zero in the game. Garrett Nussmeier went 25-31 for 273 yards and three touchdowns, while Ju’Juan Johnson rushed eight times for 43 yards and two scores. Bauer Sharp was the leading receiver for LSU with five catches for 73 yards and one touchdown in the game. The LSU defense recorded four sacks and seven tackles for loss in the win.
LSU also has wins over Clemson, Louisiana Tech, and Florida in their first three games. The Tigers are averaging 35.0 points per game with 275.0 passing yards and 116.8 rushing yards per game, while they are allowing 9.3 points against per game this season. Garrett Nussmeier has completed 68.6% of his passes for 962 yards, six touchdowns, and two interceptions, while Aaron Anderson has caught 21 passes for 293 yards. Caden Durham has led the running backs with 52 carries for 213 yards and two scores this season.
Why Ole Miss will beat LSU
- Ole Miss has won 17 of its last 18 games in Mississippi.
- LSU has lost each of its last three September games against AP-ranked teams.
- The home team has covered the spread in each of the last seven games between LSU and Ole Miss.
- LSU has failed to cover the spread in five of its last six games at Vaught-Hemingway Stadium.
- Ole Miss has won the first half in 17 of its last 19 home games against conference opponents.
Total Points Facts
- Seven of Ole Miss’ last eight September games against top-10 AP-ranked teams have gone OVER the total points line.
- Four of LSU’s last five games against conference opponents have gone UNDER the total points line.
Matchup/League Facts
- Ole Miss ranks T1st among FBS teams for 4th down conversion percentage this season (100.0).
- Ole Miss ranks 3rd among FBS teams for Q2 points per game this season (18.0).
- LSU ranks T3rd among FBS teams for interceptions this season (6).
- LSU ranks 7th among FBS teams for H2 opponent points per game this season (4.3).
Ole Miss vs LSU Prediction
Both of these teams come into this contest undefeated through four games, but Ole Miss will have the home field advantage. The Rebels have scored 41+ points in three of their four games and Chambliss has looked solid under center. LSU was a bit sloppy in their win over Florida and didn’t play well against Louisiana Tech in their second game, so I am not sure what kind of effort they will show here. This should be another fantastic game to watch, but I am worried about LSU on the road, especially with that Clemson win looking worse by the week. Take Ole Miss to get a huge win on their home field.
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