Indiana Hoosiers (5-0) vs. Oregon Ducks (5-0)
October 11, 2025 3:30 pm EDT
The Line: Oregon Ducks -10.5; Over/Under:
(Get latest betting odds)
The Indiana Hoosiers and the Oregon Ducks meet Saturday in college football action from Autzen Stadium. Here’s an Oregon vs Indiana prediction. We will look at this from a betting perspective and determine the best Oregon vs Indiana pick.
Indiana Hoosiers Betting Preview
The Hoosiers have emerged through five games unscathed so far—but their most recent outing was a pretty close one. Indiana kicked things off with a 27-14 win over Old Dominion at home, then blew out Kennesaw State 56-9 in game two. The Indiana State matchup was a 73-0 dismantling, then the Hoosiers faced off against rival neighbor Illinois. In that one Indiana plowed through the Illini 63-10 for a huge victory. Along the way the Hoosiers held Illinois to just 161 total yards (159 passing), 3.6 yards per play, nine first downs and a 1-of-10 success rate on third-down tries.
In their latest matchup versus Iowa on September 27, the Hoosiers played their tightest game yet. Indiana was all tied up 10-10 going into the fourth quarter then hit a 10-5 run for a 20-15 escape on the road. QB Fernando Mendoza finished 13-of-23 for 233 yards, two scores and an interception, and Roman Hemby added 86 yards off 15 carries to lead the rush. Tops in receiving was Elijah Sarratt with six catches for 132 yards and a score. Omar Cooper had four grabs of his own for 55 yards and a touchdown in the win.
Oregon Ducks Betting Preview
Over on the Oregon side, they’ve similarly come through the first five games without a loss—however their most recent game was also their closest so far. The Ducks didn’t have any issues with Montana State in their opener, cruising to a 59-13 blowout win. Likewise with Oklahoma State in game two on a 69-3 win and Northwestern on the road 34-14. Oregon took out in-state rival Oregon State 41-7 in game four on September 20. The Ducks finished with 585 yards total (280 rushing) and 29 first downs while holding the Beavers to just 147 total yards and 3.1 yards per play alongside eight first downs.
Back on September 27 in their most recent appearance, the Ducks took on Penn State. Despite blowing a late 10-3 lead Oregon was able to power out the road win in overtime 30-24. QB Dante Moore logged 248 yards with three scores on 29-of-39 passing. Tops in rushing was Dierre Hill with 10 carries for 82 yards, and Dakorien Moore caught seven balls for 89 yards as the team’s top receiver in the winning effort.
Indiana Hoosiers @ Oregon Ducks Betting Trends: Week 7
Oregon Ducks Player Prop Facts
- Dante Moore has thrown three or more touchdown passes in two consecutive games – equal-longest streak in the FBS.
Indiana Hoosiers Player Prop Facts
- Heading into Week 7, Fernando Mendoza ranks 1st amongst qualified players for passer rating (140.3) this season.
Matchup/League Facts
- Oregon has recorded the equal-most home wins by a margin of 15+ points of any FBS team this season (3).
- Oregon has recorded the equal-most home wins by a margin of 20+ points of any FBS team this season (3).
- Indiana has recorded the equal-most home wins by a margin of 10+ points of any FBS team this season (4).
- Indiana has recorded the equal-most home wins by a margin of 15+ points of any FBS team this season (3).
Oregon vs Indiana Prediction
I’ll lean toward Oregon but you could make a case either way here. This matchup should be one of the highlights of the weekend college football slate. The Ducks are coming off a gutsy road win over a great Penn State team in their most recent outing, notching 424 yards (248 passing), 5.4 yards per play and 20 first downs along the way. Oregon gave up 276 yards (137 passing), 4.6 yards per play and 15 first downs on defense in that one. That makes 30 or more points in every game so far this year for the Ducks, and they’ve held opponents to 14 or fewer points in four of five.
As for the Hoosiers, they were able to gut out a nice win versus a plucky Iowa team in their last outing. Indiana posted 337 yards total (233 passing) with 5.4 yards per play and a tepid 6-of-15 on third downs. Defensively the Hoosiers had a couple of picks and held the Hawkeyes to a modest 284 yards total. It’s hard telling which way this one’s going to go, but Indiana’s defense should be ready for the test. They’ve surrendered fewer than 16 points in every game this year.
